| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ELMO1; KIAA0281; Engulfment and cell motility protein 1; Protein ced-12 homolog |
| Entrez GeneID | 9844 |
| WB Predicted band size | Calculated MW: 84 kDa; Observed MW: 84 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human ELMO1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于ELMO1抗体的3篇参考文献示例(注：以下为虚构摘要，实际文献需通过数据库检索确认)：
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1. **文献名称**: *ELMO1 Antibody Reveals Its Role in Diabetic Nephropathy Pathogenesis*
**作者**: Smith A, et al.
**摘要**: 该研究通过ELMO1特异性抗体检测发现，ELMO1在糖尿病肾病患者的肾小球中高表达，并通过调控Rac1信号通路促进足细胞损伤，提示其作为治疗靶点的潜力。
2. **文献名称**: *ELMO1-Dock180 Complex Modulates Cancer Cell Invasion via Antibody-Based Functional Blockade*
**作者**: Tanaka K, et al.
**摘要**: 利用ELMO1抗体阻断ELMO1/Dock180复合物形成，显著抑制了肿瘤细胞的迁移和侵袭能力，证实其在转移性癌症中的关键作用。
3. **文献名称**: *Development of a Novel Monoclonal Antibody for ELMO1 and Its Application in Phagocytosis Assays*
**作者**: Chen L, et al.
**摘要**: 本研究开发了一种高特异性ELMO1单克隆抗体，并应用于巨噬细胞吞噬功能实验，发现ELMO1通过调节细胞骨架重组影响吞噬效率。
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**建议**：实际文献可通过PubMed或Google Scholar搜索关键词“ELMO1 antibody”、“ELMO1 function”等获取，并优先选择近5年发表、高影响力期刊的研究。
The ELMO1 (Engulfment and Cell Motility Protein 1) antibody is a key reagent used to study the ELMO1 protein, which plays a critical role in regulating cytoskeletal dynamics, cell migration, and phagocytosis. ELMO1 functions as an adaptor protein, interacting with Dock180 (Dedicator of Cytokinesis 1) to activate Rac GTPases, thereby promoting actin reorganization and intracellular signaling. This pathway is essential for processes like immune cell trafficking, neuronal development, and tissue remodeling. Dysregulation of ELMO1 has been implicated in pathological conditions, including cancer metastasis, inflammatory diseases, and kidney disorders such as diabetic nephropathy.
ELMO1 antibodies are widely employed in research to detect protein expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. They have been instrumental in identifying ELMO1's role in tumor cell invasion, where its overexpression correlates with enhanced metastatic potential. In immune contexts, ELMO1 antibodies help elucidate mechanisms of phagocytic clearance of apoptotic cells and pathogens. Additionally, studies using these antibodies have linked ELMO1 polymorphisms to chronic kidney disease susceptibility, highlighting its clinical relevance. The development of specific ELMO1 antibodies continues to advance understanding of cellular motility pathways and their therapeutic targeting in disease.
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