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Rabbit Monoclonal DAZAP1 Antibody

  • 中文名： DAZAP1抗体
  • 别    名： Deleted in azoospermia-associated protein 1
货号: IPDX21297
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesDeleted in azoospermia-associated protein 1
Entrez GeneID26528
WB Predicted band sizeCalculated MW: 43 kDa; Observed MW: 43 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenRecombinant protein of human DAZAP1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于DAZAP1抗体的3篇参考文献(示例为模拟生成内容，实际文献需根据具体数据库检索)：

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1. **文献名称**: "Characterization and Application of a Novel DAZAP1-Specific Antibody in Mammalian Tissues"

**作者**: Smith J, et al.

**摘要**: 该研究开发并验证了一种针对DAZAP1蛋白的高特异性多克隆抗体，通过免疫印迹和免疫荧光技术，证实其在多种哺乳动物组织中的表达模式，并发现DAZAP1在睾丸和大脑中表达显著上调。

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2. **文献名称**: "DAZAP1 Regulates mRNA Splicing and Its Dysregulation Promotes Cancer Metastasis"

**作者**: Chen L, et al.

**摘要**: 研究利用DAZAP1抗体进行免疫沉淀结合质谱分析，揭示了DAZAP1在mRNA剪接中的功能，并证明其在乳腺癌细胞中异常表达可通过调控靶基因剪接促进转移。

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3. **文献名称**: "DAZAP1 Antibody-Based Detection of Protein Aggregation in Neurodegenerative Disorders"

**作者**: Kim S, et al.

**摘要**: 通过DAZAP1抗体进行脑组织免疫组化分析，发现DAZAP1蛋白在阿尔茨海默病模型中与tau蛋白异常共定位，提示其可能参与神经退行性病变的病理过程。

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如需获取真实文献，建议在PubMed或Google Scholar中检索关键词“DAZAP1 antibody”或结合具体研究领域筛选。

背景信息

The DAZAP1 (Deleted in Azoospermia Associated Protein 1) antibody is a tool used to study the DAZAP1 protein, a ubiquitously expressed RNA-binding protein implicated in diverse cellular processes. DAZAP1 interacts with mRNA molecules, regulating their stability, transport, and translation. It plays roles in spermatogenesis, neuronal development, and cell proliferation, with studies linking it to cancer progression, neurodevelopmental disorders, and infertility. The protein contains two RNA-binding domains and is involved in pathways like Wnt/β-catenin signaling. Antibodies targeting DAZAP1 enable researchers to detect its expression and localization in tissues or cultured cells via techniques such as Western blot, immunohistochemistry, and immunofluorescence. These studies help elucidate DAZAP1’s functional mechanisms in disease contexts, including its potential as a biomarker or therapeutic target. Commercial DAZAP1 antibodies are typically validated for specificity across human, mouse, and rat models, supporting cross-species research. Recent work explores its involvement in alternative splicing, stress granule formation, and interactions with other RNA-binding proteins, highlighting its multifaceted role in post-transcriptional gene regulation.

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