| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BMP2; BMP2A; Bone morphogenetic protein 2; BMP-2; Bone morphogenetic protein 2A; BMP-2A |
| Entrez GeneID | 650 |
| WB Predicted band size | Calculated MW: 45 kDa; Observed MW: 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human BMP2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3-4条关于BMP2抗体的虚构参考文献示例(内容基于学术研究的常见方向，仅供示例参考)：
1. **文献名称**: *"A Monoclonal Antibody Targeting BMP2 Reveals Its Role in Skeletal Development"*
**作者**: Smith J, et al.
**摘要**: 本研究开发了一种高特异性抗BMP2单克隆抗体，通过免疫组织化学和Western blot验证其在哺乳动物骨骼组织中的检测能力，揭示了BMP2在胚胎骨骼发育中的时空表达模式。
2. **文献名称**: *"BMP2 Neutralizing Antibody Attenuates Tumor-Induced Osteolysis in Vivo"*
**作者**: Zhang Y, et al.
**摘要**: 通过使用BMP2中和抗体阻断其信号通路，研究者证明了BMP2在肿瘤转移性骨溶解中的关键作用，为靶向BMP2的癌症治疗提供了实验依据。
3. **文献名称**: *"Comparative Evaluation of Commercial BMP2 Antibodies for ELISA Applications"*
**作者**: Lee H, et al.
**摘要**: 该研究系统评估了多种市售BMP2抗体的灵敏度、交叉反应性和稳定性，为临床检测和科研中选择合适试剂提供了参考数据。
4. **文献名称**: *"BMP2 Antibody-Based Biosensor for Early Diagnosis of Osteoporosis"*
**作者**: Gupta R, et al.
**摘要**: 研究团队利用抗BMP2抗体构建了一种电化学生物传感器，实现了血清中低浓度BMP2的高效检测，为骨质疏松症的早期诊断提供了新方法。
(注：以上文献为模拟示例，实际引用需查询真实数据库如PubMed、Web of Science等。)
BMP2 (Bone Morphogenetic Protein 2) antibodies are immunological tools designed to detect or modulate BMP2. a key growth factor in the TGF-β superfamily. BMP2 plays critical roles in embryonic development, skeletal formation, and tissue repair by regulating osteogenic differentiation, cell proliferation, and apoptosis. It is widely studied in bone regeneration, developmental biology, and diseases like osteoporosis or cancer.
BMP2 antibodies, including monoclonal and polyclonal types, are utilized in techniques like Western blotting, immunohistochemistry, and ELISA to quantify BMP2 expression or track its localization in tissues. In research, they help elucidate BMP2 signaling pathways, particularly its interaction with receptors (BMPR1/2) and downstream SMAD proteins.
Clinically, BMP2 antibodies have therapeutic potential. For instance, they may inhibit BMP2-driven pathways in cancers where BMP2 overexpression promotes tumor growth or metastasis. Conversely, recombinant BMP2 is used in bone graft therapies, and antibodies can monitor its efficacy or side effects. However, BMP2’s dual role in cancer (pro-tumor or suppressive depending on context) complicates therapeutic applications, necessitating context-specific antibody use.
Challenges include cross-reactivity with homologous BMPs and variability in assay conditions. Ongoing research aims to refine antibody specificity and explore engineered variants for targeted therapies. Overall, BMP2 antibodies remain vital for both basic research and translational medicine.
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