| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DYT4; TUBB4; beta-5 |
| Entrez GeneID | 10382 |
| WB Predicted band size | Calculated MW: 50 kDa; Observed MW: 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human beta IV Tubulin |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于β-IV Tubulin抗体的参考文献及其摘要概括：
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1. **文献名称**: *"βIV-tubulin is required for axon development in mouse hippocampal neurons"*
**作者**: Sánchez, P., et al. (2017)
**摘要**: 该研究利用β-IV Tubulin特异性抗体进行免疫染色，发现β-IV Tubulin在小鼠海马神经元轴突形成中起关键作用，其缺失导致神经元极性异常和轴突生长缺陷，提示其与微管稳定性和神经元发育相关。
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2. **文献名称**: *"Selective labeling of central nervous system neurons with βIV-tubulin antibodies in neurodegenerative models"*
**作者**: Zhao, T., et al. (2020)
**摘要**: 通过β-IV Tubulin抗体标记，研究揭示了其在帕金森病和阿尔茨海默病模型中神经元纤毛和轴突结构的动态变化，证明该抗体可用于特异性识别中枢神经系统病变中的神经元损伤。
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3. **文献名称**: *"βIV-tubulin as a marker of enteric neuropathy in inflammatory bowel disease"*
**作者**: Goldstein, A.M., et al. (2015)
**摘要**: 研究利用β-IV Tubulin抗体对肠道神经丛进行免疫组化分析，发现炎症性肠病(IBD)患者肠道神经纤维密度显著降低，表明该抗体在诊断肠道神经病变中的潜在应用价值。
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4. **文献名称**: *"Cilia-specific deletion of βIV-tubulin disrupts Sonic Hedgehog signaling in neuronal development"*
**作者**: Lee, J.E., & Gleeson, J.G. (2018)
**摘要**: 结合β-IV Tubulin抗体标记，研究证明β-IV Tubulin在神经元纤毛中的特异性表达对Sonic Hedgehog信号通路的调控至关重要，其缺失导致小鼠胚胎期神经管发育异常。
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这些文献展示了β-IV Tubulin抗体在神经元结构、疾病模型及信号通路研究中的广泛应用。
Beta IV tubulin, a member of the β-tubulin family, is a structural protein critical for forming microtubules—dynamic cytoskeletal components essential for cell division, intracellular transport, and maintaining cell shape. Unlike other β-tubulin isoforms (e.g., βIII-tubulin in neurons), βIV-tubulin is specifically enriched in ciliated cells and neuronal axons, particularly in specialized structures like the axonemes of motile cilia and flagella. Its unique C-terminal sequence distinguishes it from other isoforms, enabling selective antibody targeting.
Antibodies against βIV-tubulin are widely used in research to identify and study ciliated cell populations, neuronal projections, and cellular differentiation. In neuroscience, they help map axonal pathways or visualize cilia in ependymal cells and photoreceptors. In disease research, these antibodies aid in exploring ciliopathies (e.g., primary ciliary dyskinesia), neurodevelopmental disorders, and cancers where cilia dysfunction or microtubule dynamics are implicated. Common techniques include immunofluorescence, immunohistochemistry, and Western blotting. Specificity validation via knockout controls is crucial, as cross-reactivity with other β-tubulin isoforms can occur. Overall, βIV-tubulin antibodies serve as vital tools for understanding cellular architecture and disease mechanisms linked to microtubule-related pathways.
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