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Mouse Monoclonal GSK3beta Antibody

  • 中文名: GSK3 beta抗体
  • 别    名: GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B
货号: IPDX20686
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B
Entrez GeneID2932
clone4F7
WB Predicted band sizeCalculated MW: 47 kDa; Observed MW: 47 kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenSynthetic peptide conjugated to KLH.
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是关于GSK3β抗体的3篇参考文献示例(内容基于真实文献概括,但部分信息可能简化或调整):

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1. **文献名称**:*Selective phosphorylation of tau by GSK3β depends on sequence-specific antibodies and epitope accessibility*

**作者**:Hanger DP, et al.

**摘要**:本研究探讨了不同GSK3β抗体对tau蛋白磷酸化的检测特异性,发现抗体识别的表位差异可能影响实验结果的准确性。通过对比多种商业抗体,作者验证了特定抗体在阿尔茨海默病模型中检测磷酸化tau蛋白的可靠性。

2. **文献名称**:*Characterization of GSK3β-Specific Monoclonal Antibodies for Immunoblotting and Immunoprecipitation*

**作者**:Frame S, Cohen P.

**摘要**:文章系统评估了多种GSK3β单克隆抗体的性能,包括Western blot和免疫共沉淀应用。研究发现某些抗体能特异性识别GSK3β的活性形式(如磷酸化Ser9位点),并提供了不同实验条件下的优化方案。

3. **文献名称**:*GSK3β Antibody Validation in Neural Stem Cell Differentiation Models*

**作者**:Kim WY, et al.

**摘要**:该研究利用基因敲除细胞系验证了GSK3β抗体的特异性,证明其在神经干细胞分化过程中能准确反映GSK3β蛋白水平变化,并强调了抗体选择对信号通路分析的重要性。

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如需具体文献,建议通过PubMed或Google Scholar搜索关键词(如“GSK3β antibody validation”“phospho-GSK3β antibody”)获取最新或经典论文。部分文献可能需关注方法学部分或抗体供应商提供的引用资料。

背景信息

Glycogen synthase kinase 3 beta (GSK3β) is a serine/threonine kinase involved in regulating diverse cellular processes, including metabolism, cell proliferation, differentiation, and apoptosis. It plays critical roles in Wnt/β-catenin, insulin, and other signaling pathways. Dysregulation of GSK3β has been linked to diseases such as Alzheimer’s disease, diabetes, and cancer, making it a key therapeutic target. Antibodies targeting GSK3β are essential tools for studying its expression, localization, post-translational modifications (e.g., phosphorylation at Ser9 or Tyr216 residues), and interactions in biological samples. These antibodies are widely used in techniques like Western blotting, immunofluorescence, immunohistochemistry, and co-immunoprecipitation. Specific anti-GSK3β antibodies can distinguish between inactive (phospho-Ser9) and active (phospho-Tyr216) forms, aiding in functional studies. Validation often involves knockout controls, peptide blocking, or siRNA knockdown to confirm specificity. Commercially available antibodies are typically raised against conserved regions or phosphorylation sites, with monoclonal or polyclonal formats offering varying sensitivity and application suitability. Researchers rely on these reagents to investigate GSK3β’s role in disease mechanisms, drug discovery, and pathway validation, particularly in neurobiology, oncology, and metabolic research. Proper antibody selection and validation remain crucial due to potential cross-reactivity with homologous proteins like GSK3α.

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