Rabbit Monoclonal Calcipressin1 Antibody

Calcipressin-1 (also known as DSCR1 or RCAN1) is a key regulatory protein involved in the calcineurin-NFAT signaling pathway, which plays critical roles in cellular processes like immune response, cardiac development, and neuronal plasticity. As an endogenous inhibitor of calcineurin phosphatase activity, Calcipressin-1 modulates calcium-dependent signaling by binding to calcineurin and suppressing its function. Dysregulation of Calcipressin-1 has been implicated in pathological conditions, including Down syndrome, Alzheimer’s disease, and cardiovascular disorders. Antibodies targeting Calcipressin-1 are essential tools for studying its expression, localization, and interactions in both physiological and disease contexts. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research into its dual role as a stress-responsive protein and a disease biomarker. Studies using Calcipressin-1 antibodies have revealed its tissue-specific expression patterns and dynamic regulation under oxidative or metabolic stress. Additionally, they help explore its contradictory roles in promoting or inhibiting apoptosis, depending on cellular context. Reliable Calcipressin-1 antibodies are crucial for advancing understanding of calcineurin signaling and developing therapeutic strategies for related diseases.