| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CALU; Calumenin 1; Calumenin 2; Calumenin; Crocalbin;;Calumenin |
| WB Predicted band size | Calculated MW: 37 kDa ; Observed MW: 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Calumenin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Calumenin抗体的示例参考文献(信息为示例性质，具体文献需通过学术数据库验证)：
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1. **文献名称**: *Calumenin interacts with serum amyloid A protein and regulates its cytotoxicity*
**作者**: Wang Y. et al.
**摘要**: 研究揭示了Calumenin通过结合血清淀粉样蛋白A(SAA)抑制其纤维形成，减轻细胞毒性。实验中利用特异性Calumenin抗体验证两者相互作用，为淀粉样变性疾病的机制提供新见解。
2. **文献名称**: *Role of Calumenin in platelet function and thrombosis*
**作者**: Zhang L. et al.
**摘要**: 通过免疫共沉淀和Western blot分析(使用抗Calumenin单克隆抗体)，发现Calumenin缺失导致血小板活化异常，提示其在血栓形成中的调控作用。
3. **文献名称**: *Calumenin as a novel biomarker for hepatocellular carcinoma*
**作者**: Tanaka K. et al.
**摘要**: 研究通过免疫组化(Calumenin抗体标记)发现肝癌组织中Calumenin高表达，且与患者预后不良相关，提示其作为潜在诊断标志物的价值。
4. **文献名称**: *Antibody-based targeting of Calumenin in breast cancer cells*
**作者**: Chen H. et al.
**摘要**: 开发了一种针对Calumenin的多克隆抗体，证实其可抑制乳腺癌细胞迁移和侵袭，为靶向治疗提供实验依据。
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**提示**：以上为示例内容，实际文献需通过PubMed、Web of Science等平台检索关键词“Calumenin antibody”或“CALU protein”获取。研究多集中于Calumenin在钙信号、癌症、心血管疾病及蛋白质折叠中的作用。
Calumenin is a calcium-binding protein belonging to the CREC (Cab45. reticulocalbin, ERC-45. calumenin) family, primarily localized in the endoplasmic reticulum (ER) and secretory pathway. It plays roles in calcium homeostasis, protein folding, and cell signaling. Calumenin interacts with enzymes like γ-glutamyl carboxylase and sarcoplasmic/endoplasmic reticulum Ca²⁺-ATPase (SERCA), influencing processes such as blood coagulation and cardiac muscle contraction. Dysregulation of calumenin has been linked to cardiovascular diseases, cancer, and metabolic disorders, highlighting its biological significance.
Calumenin antibodies are essential tools for detecting and studying this protein in research. They enable the visualization of calumenin's expression, localization, and interactions via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are often validated for specificity using knockout cell lines or tissues to minimize cross-reactivity. Commercial calumenin antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions). Applications include investigating calumenin's role in ER stress, calcium signaling pathways, and disease mechanisms. Researchers should select antibodies based on intended applications, species reactivity (human, mouse, rat), and validation data provided by suppliers. Recent studies also explore calumenin's potential as a therapeutic target or biomarker, driving demand for reliable antibodies in both basic and translational research contexts.
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