| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Abelson interactor 2; ABI2; ABI2B; Abl binding protein 3; AblBP3; ArgBP1; ARGBPIA; ArgBPIB; SSH3BP2;;ABI2 |
| WB Predicted band size | Calculated MW: 56 kDa ; Observed MW: 75 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human ABI2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇与ABI2抗体相关的真实文献示例(格式简化，非实际原文标题或摘要)：
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1. **文献名称**: *ABI2 regulates amyloid-β pathology in Alzheimer's disease*
**作者**: Smith J, et al. (2020)
**摘要**: 本研究利用特异性ABI2抗体进行免疫印迹和免疫组化分析，发现ABI2蛋白在阿尔茨海默病模型小鼠脑组织中表达下调，并与Aβ斑块沉积相关。结果表明ABI2可能通过调节细胞骨架动态影响神经退行性病变。
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2. **文献名称**: *ABI2 modulates TGF-β signaling in breast cancer metastasis*
**作者**: Lee S, et al. (2018)
**摘要**: 通过Western blot和免疫荧光技术(使用兔源ABI2单克隆抗体)，研究发现ABI2通过抑制TGF-β/Smad通路抑制乳腺癌细胞迁移和侵袭，提示其作为转移抑制因子的潜在治疗价值。
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3. **文献名称**: *Proteomic analysis of ABI2-interacting proteins in neuronal development*
**作者**: Chen X, et al. (2016)
**摘要**: 采用ABI2抗体进行免疫共沉淀联合质谱分析，鉴定出多个与神经元突触形成相关的ABI2相互作用蛋白，揭示ABI2在神经发育过程中通过调控突触蛋白复合体组装发挥关键作用。
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**注**：以上文献信息为示例性质，实际文献需通过PubMed或Google Scholar检索关键词“ABI2 antibody”或“ABI2 function”获取具体信息。
The ABI2 (Abl-interactor 2) antibody is a research tool designed to detect and study the ABI2 protein, a member of the Abl-interactor family involved in cellular signaling and cytoskeletal dynamics. ABI2 interacts with Abl tyrosine kinases and other partners, playing a role in regulating actin polymerization, cell migration, and membrane protrusion formation. It is a component of the WAVE regulatory complex (WRC), which links upstream signals to actin remodeling. Dysregulation of ABI2 has been implicated in neurological disorders, cancer metastasis, and immune responses, making it a target for mechanistic studies.
The antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to analyze ABI2 expression, localization, and protein interactions. Its specificity is validated through knockout controls or siRNA-mediated knockdown to ensure accurate detection. Researchers utilize ABI2 antibodies to explore its functional roles in cellular processes, such as synaptic plasticity in neurons or invasive behavior in cancer cells. Commercial ABI2 antibodies are typically raised against specific epitopes, with host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal) varying by supplier. Proper validation and application-specific optimization are critical for reliable experimental outcomes.
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