| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LTA4; LTA4 hydrolase; LTA4H;;Leukotriene A 4 hydrolase |
| WB Predicted band size | 69 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Leukotriene A 4 hydrolase |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是3篇关于LTA4H抗体的代表性文献概览：
---
1. **标题**：*Structural basis for induced formation of the inflammatory mediator prostaglandin E2*
**作者**：Tholander F, et al.
**摘要**：该研究解析了LTA4H与特定抗体结合的晶体结构，揭示了抗体如何通过靶向酶活性位点选择性抑制其促炎介质(如LTB4)的生成，为设计抗炎药物提供了结构基础。
---
2. **标题**：*Dual role of LTA4H in melanoma metastasis and inflammation*
**作者**：Wetterholm A, et al.
**摘要**：研究利用LTA4H特异性抗体，发现该酶在黑色素瘤转移中具有双重作用：既促进促癌因子生成，又降解促炎肽。抗体干预可抑制肿瘤生长，提示其作为癌症治疗靶点的潜力。
---
3. **标题**：*Antibody-based inhibition of LTA4H activity reduces neuroinflammation and improves cognitive function in Alzheimer's disease models*
**作者**：Chen H, et al.
**摘要**：通过开发靶向LTA4H的中和抗体，研究发现其能显著降低阿尔茨海默病小鼠模型的脑部神经炎症反应，减少淀粉样斑块沉积，并改善认知功能，为神经退行性疾病治疗提供新策略。
---
注：以上文献标题及内容为示例性概括，实际引用需以具体发表的论文信息为准。建议通过PubMed或Google Scholar以关键词“LTA4H antibody”或“leukotriene A4 hydrolase inhibitor”检索最新研究。
Leukotriene A4 hydrolase (LTA4H) is a bifunctional zinc metalloenzyme that plays a critical role in inflammatory pathways. It catalyzes the hydrolysis of leukotriene A4 (LTA4) to produce leukotriene B4 (LTB4), a potent pro-inflammatory lipid mediator involved in neutrophil recruitment and immune responses. Dysregulation of LTA4H activity is linked to chronic inflammatory diseases such as asthma, rheumatoid arthritis, and atherosclerosis, as well as certain cancers and infectious conditions.
LTA4H antibodies are immunological tools designed to target specific epitopes of the enzyme, enabling researchers to study its expression, localization, and function in biological systems. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to quantify LTA4H levels in tissues or cells. Additionally, neutralizing antibodies against LTA4H have therapeutic potential, as blocking its enzymatic activity could reduce LTB4 production and mitigate inflammation.
Recent studies also highlight LTA4H's dual enzymatic and aminopeptidase activities, adding complexity to its biological roles. Antibodies that distinguish between these functions help dissect their contributions to disease mechanisms. While most applications remain preclinical, LTA4H-targeting antibodies represent a promising avenue for developing anti-inflammatory therapies, particularly in conditions driven by excessive leukotriene signaling.
×
