Rabbit Monoclonal KLC3 Antibody

The KLC3 antibody targets kinesin light chain 3 (KLC3), a component of the kinesin-1 motor protein complex responsible for intracellular cargo transport along microtubules. KLC3 is primarily expressed in the testis and plays a critical role in spermatogenesis, particularly in the structural organization and acrosome formation of developing sperm cells. It interacts with the kinesin heavy chain (KHC) to regulate vesicle trafficking, organelle positioning, and cytoskeletal dynamics during germ cell maturation. Dysregulation of KLC3 has been linked to male infertility due to impaired sperm morphogenesis. Beyond reproductive biology, KLC3 is implicated in certain cancers, including gliomas and breast cancer, where aberrant expression may influence tumor progression or metastasis. The KLC3 antibody is widely utilized in research to study protein localization, expression patterns, and functional interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its application extends to investigating molecular mechanisms underlying fertility disorders and cancer pathogenesis, offering potential insights for therapeutic targeting. Recent studies also explore its role in neurological contexts, though this remains less characterized.