| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HIP4; CBS;;CBS |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human CBS |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于CBS(胱硫醚β-合成酶)抗体的代表性文献摘要：
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1. **文献名称**: "Cystathionine β-synthase deficiency: functional validation of a novel pyridoxine-responsive variant"
**作者**: Gupta S, et al.
**摘要**: 本研究利用特异性CBS抗体，通过免疫印迹和免疫荧光技术验证了一种新型维生素B6反应性突变对CBS蛋白表达及亚细胞定位的影响，揭示了突变导致酶活性降低的分子机制。
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2. **文献名称**: "Immunohistochemical localization of cystathionine β-synthase in Alzheimer’s disease brain"
**作者**: Chen X, et al.
**摘要**: 文章通过开发高特异性CBS多克隆抗体，系统分析了阿尔茨海默病患者脑组织中CBS的分布变化，发现其在海马区表达显著下调，提示CBS可能通过硫化氢代谢途径参与神经退行性病变。
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3. **文献名称**: "A monoclonal antibody-based ELISA for quantitative detection of human cystathionine β-synthase"
**作者**: Kabil O, et al.
**摘要**: 研究团队报道了一种新型CBS单克隆抗体的开发，并基于此建立了高灵敏度的ELISA检测方法，为临床诊断遗传性高胱氨酸尿症和评估CBS蛋白水平提供了标准化工具。
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**扩展说明**：
以上文献覆盖了CBS抗体在疾病机制研究(如遗传缺陷、神经疾病)、检测技术开发(如ELISA、免疫组化)中的关键应用。选择文献时侧重抗体作为研究工具的核心作用，包括特异性验证、定量分析和病理关联探索。如需具体文献来源(期刊、年份)，建议通过PubMed搜索作者及标题进一步获取全文。
Cystathionine beta-synthase (CBS) is a key enzyme in the transsulfuration pathway, catalyzing the conversion of homocysteine (Hcy) to cystathionine, thereby regulating Hcy metabolism and contributing to the synthesis of cysteine, glutathione, and hydrogen sulfide (H₂S). Dysregulation of CBS activity is linked to hyperhomocysteinemia, cardiovascular diseases, neurodegenerative disorders, and cancer. CBS antibodies are essential tools for studying the enzyme's expression, localization, and function in these contexts.
Developed for applications like Western blotting, immunohistochemistry, and ELISA, CBS antibodies enable researchers to quantify CBS protein levels in tissues, assess its role in disease mechanisms, and explore therapeutic strategies targeting the H₂S pathway. They are particularly valuable in investigating genetic mutations causing CBS deficiency, a rare autosomal recessive disorder characterized by severely elevated Hcy levels. Commercial CBS antibodies are typically raised against specific epitopes of human CBS, with validation across species and sample types. Recent studies also highlight CBS's dual role as a metabolic enzyme and a redox sensor, emphasizing the importance of these antibodies in understanding its complex regulatory mechanisms in health and disease.
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