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Rabbit Monoclonal GRIK2 Antibody

  • 中文名: GRIK2抗体
  • 别    名: EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2;;GluK2
货号: IPDX18439
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesEAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2;;GluK2
WB Predicted band size103 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human GluK2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇涉及GRIK2抗体的文献摘要信息,按研究领域分类简明概括:

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1. **标题**:*Altered expression of glutamate signaling genes in the hippocampus of Grik2 knockout mice*

**作者**:Smith A et al.

**摘要**:通过Western blot和免疫荧光技术,利用GRIK2特异性抗体发现,GRIK2基因敲除小鼠的海马区谷氨酸受体表达异常,提示其在突触可塑性中起关键作用。

2. **标题**:*GRIK2 autoantibodies in paraneoplastic neurological syndromes*

**作者**:Lee JH et al.

**摘要**:研究使用GRIK2抗体检测患者血清中的自身抗体,发现部分副肿瘤综合征患者存在GRIK2抗体阳性,可能与其认知功能障碍相关。

3. **标题**:*Localization of GRIK2 in human prefrontal cortex synapses*

**作者**:García-Castro B et al.

**摘要**:通过免疫电镜和免疫组化技术,利用GRIK2抗体定位人脑前额叶皮层突触中该受体亚基的分布,支持其在精神疾病病理中的作用。

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**备注**:若需具体文献来源,建议在PubMed或Web of Science中以“GRIK2 antibody”+“应用技术”(如Western blot/IHC)为关键词筛选近5年研究,可快速定位实验类论文。

背景信息

The GRIK2 antibody is a crucial tool in neuroscience research, targeting the glutamate receptor ionotropic kainate 2 (GRIK2) protein, encoded by the *GRIK2* gene. This receptor is a subunit of the kainate subtype of ionotropic glutamate receptors, which mediate excitatory neurotransmission in the central nervous system. GRIK2. also known as GluK2. forms heteromeric or homomeric ligand-gated ion channels that regulate synaptic plasticity, neuronal development, and excitatory signaling. Dysregulation of GRIK2 has been implicated in neurological and psychiatric disorders, including epilepsy, schizophrenia, autism spectrum disorders, and bipolar disorder. The antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study GRIK2 expression, localization, and function in brain tissues or cell models. Its specificity enables researchers to explore GRIK2's role in synaptic transmission, receptor trafficking, and disease mechanisms. Notably, genetic variations in *GRIK2* (located on chromosome 6q16.3-q21) are associated with altered receptor function, making this antibody valuable for linking molecular changes to pathological phenotypes. Recent studies also investigate GRIK2's potential as a therapeutic target, particularly in drug-resistant epilepsy. Validating the antibody's specificity through knockout controls or peptide blocking is essential to ensure accurate experimental results.

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