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Rabbit Monoclonal SRD5A2 Antibody

  • 中文名: SRD5A2抗体
  • 别    名: SRD5A2; 5 alpha-SR2; S5AR 2; Type II 5-alpha reductase; SR type 2; Steroid 5-alpha-reductase 2;;SRD5A2
货号: IPDX18437
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSRD5A2; 5 alpha-SR2; S5AR 2; Type II 5-alpha reductase; SR type 2; Steroid 5-alpha-reductase 2;;SRD5A2
WB Predicted band size28 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenA synthesized peptide derived from human SRD5A2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于SRD5A2抗体的3篇参考文献示例(注:内容为模拟虚构,仅供参考格式):

1. **文献名称**:*Development and Validation of a Monoclonal Antibody for SRD5A2 in Human Prostate Tissue*

**作者**:Smith J, et al.

**摘要**:本研究开发了一种针对SRD5A2的高特异性单克隆抗体,并通过免疫组化和Western blot验证其在人类前列腺组织中的表达,证实其在良性前列腺增生与前列腺癌中的差异表达。

2. **文献名称**:*Immunohistochemical Analysis of SRD5A2 in 5α-Reductase Deficiency Patients*

**作者**:Lee H, et al.

**摘要**:利用SRD5A2抗体对5α-还原酶缺乏症患者的生殖器皮肤样本进行免疫染色,发现SRD5A2蛋白表达显著降低,为疾病诊断提供了分子依据。

3. **文献名称**:*SRD5A2 Antibody-Based Detection of Enzyme Localization in Androgen-Dependent Tissues*

**作者**:Garcia R, et al.

**摘要**:通过免疫荧光技术结合SRD5A2抗体,揭示该酶在雄性激素依赖性组织(如前列腺、毛囊)中的亚细胞定位,并探讨其与雄激素代谢途径的关联。

(注:以上文献为示例,实际引用需检索PubMed、Web of Science等数据库获取真实文献。)

背景信息

The SRD5A2 antibody targets steroid 5-alpha reductase type 2. an enzyme encoded by the SRD5A2 gene. This enzyme plays a critical role in steroid metabolism, specifically converting testosterone to dihydrotestosterone (DHT), a potent androgen essential for male sexual development and function. SRD5A2 is predominantly expressed in androgen-sensitive tissues, including the prostate, testes, and skin.

Antibodies against SRD5A2 are widely used in research to study its expression, localization, and regulation in normal physiology and disease. Mutations in SRD5A2 cause 5-alpha reductase deficiency, a rare disorder characterized by undervirilization in genetic males, making the antibody a key tool for diagnosing this condition. Additionally, SRD5A2 is implicated in pathologies such as benign prostatic hyperplasia (BPH), prostate cancer, and hirsutism, where dysregulated DHT synthesis drives disease progression.

In laboratory settings, SRD5A2 antibodies are employed in techniques like immunohistochemistry, Western blotting, and ELISA to assess protein levels in tissue samples or cell lines. These studies help elucidate the enzyme’s role in androgen signaling pathways and evaluate therapeutic interventions targeting SRD5A2. such as 5-alpha reductase inhibitors (e.g., finasteride). The antibody’s specificity and reliability are crucial for advancing research in endocrinology, oncology, and reproductive medicine.

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