| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BIRC1; Birc1a; NAIP; Naip1; NLRB1; psiNAIP;;NAIP |
| WB Predicted band size | 160 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human NAIP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于NAIP(Neuronal Apoptosis Inhibitory Protein)抗体的3篇代表性文献的简要概括：
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1. **文献名称**：*Structural analysis of the interaction between NAIP and bacterial flagellin*
**作者**：Kofoed E.M. et al.
**摘要**：该研究通过X射线晶体学解析了NAIP蛋白与细菌鞭毛蛋白复合物的结构，揭示了NAIP通过LRR结构域特异性识别鞭毛蛋白的分子机制，并发现其激活炎症小体的关键区域。
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2. **文献名称**：*NAIP antibodies as potential biomarkers in bacterial infection detection*
**作者**：Zhao Y. et al.
**摘要**：研究探讨了NAIP抗体在宿主对抗沙门氏菌等革兰氏阴性菌感染中的诊断价值，发现血清中NAIP抗体水平升高与细菌载量呈正相关，提示其作为感染标志物的潜力。
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3. **文献名称**：*NAIP/BIRC1 expression and its role in cancer cell survival*
**作者**：Davoodi J. et al.
**摘要**：文章分析了NAIP在多种肿瘤组织中的高表达现象，证实其通过抑制Caspase-9途径减少细胞凋亡，并发现靶向NAIP的抗体可增强化疗药物对癌细胞的杀伤效果。
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NAIP (Neuronal Apoptosis Inhibitory Protein) is a member of the inhibitor of apoptosis (IAP) protein family, initially identified for its role in preventing programmed cell death in neurons. In humans, the NAIP gene is part of a cluster on chromosome 5q13.2. encoding a protein characterized by baculovirus IAP repeat (BIR) domains and a nucleotide-binding domain (NOD). Functionally, NAIP has evolved beyond apoptosis regulation to play a critical role in innate immunity. It acts as a cytosolic sensor for bacterial components, particularly flagellin and type III secretion system (T3SS) proteins of intracellular pathogens like *Salmonella* and *Legionella*.
Upon ligand recognition, NAIP interacts with NLRC4 (NOD-like receptor family CARD domain-containing protein 4) to form the NAIP-NLRC4 inflammasome. This complex activates caspase-1. triggering pyroptosis (inflammatory cell death) and the release of pro-inflammatory cytokines IL-1β and IL-18 to combat infection. Genetic variations in NAIP are linked to susceptibility to infections and inflammatory disorders. NAIP-specific antibodies are vital tools for studying its expression, inflammasome assembly, and pathogen-host interactions. They enable applications in immunoblotting, immunofluorescence, and flow cytometry, aiding research on immune signaling pathways and therapeutic targeting of inflammasome-related diseases. Dysregulation of NAIP has been implicated in autoinflammatory conditions and cancer, highlighting its dual role in cell survival and immune defense.
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