| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ADIP; SSX2IP;;SSX2IP |
| WB Predicted band size | Calculated MW: 71 kDa ; Observed MW: 74,76 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human SSX2IP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于SSX2IP抗体的示例参考文献(注：部分内容为虚构示例，实际文献请通过学术数据库查询)：
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1. **文献名称**：*SSX2IP promotes acute myeloid leukemia progression via modulating cell adhesion*
**作者**：Chen L, et al.
**摘要**：本研究利用SSX2IP抗体通过免疫印迹和免疫荧光技术，揭示了SSX2IP在急性髓系白血病(AML)细胞中高表达，并通过调控黏着斑复合体促进白血病细胞的迁移和侵袭。
2. **文献名称**：*SSX2IP interacts with centrosomal proteins and regulates mitotic spindle assembly*
**作者**：Tanaka K, et al.
**摘要**：通过SSX2IP抗体的共定位实验，发现SSX2IP与中心体蛋白CEP85相互作用，参与有丝分裂纺锤体组装，其缺失导致染色体分离异常和细胞周期停滞。
3. **文献名称**：*SSX2IP as a novel biomarker in colorectal cancer: Insights from immunohistochemical analysis*
**作者**：Müller R, et al.
**摘要**：采用SSX2IP抗体对结直肠癌组织进行免疫组化染色，发现SSX2IP表达与肿瘤转移正相关，提示其可作为预后不良的生物标志物。
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建议通过PubMed、Google Scholar等平台搜索关键词“SSX2IP antibody”或“SSX2IP function”获取真实文献。
The SSX2IP (Synovial Sarcoma X Breakpoint 2 Interacting Protein) antibody is a tool used to study the SSX2IP protein, which plays roles in cell adhesion, migration, and intracellular signaling. SSX2IP, also known as AF-6-like or ADIP, interacts with multiple partners, including the small GTPase Rap1 and the cytoskeletal protein α-actinin. It is implicated in organizing cell-cell junctions, particularly in epithelial and endothelial cells, by linking membrane receptors to the actin cytoskeleton.
Research highlights its involvement in cancer biology, as SSX2IP overexpression is observed in malignancies like melanoma, acute myeloid leukemia (AML), and glioblastoma. In melanoma, SSX2IP promotes metastatic behavior by enhancing cell migration via Rac1 activation. In AML, it contributes to leukemogenesis through interactions with the KIT receptor. The antibody enables detection of SSX2IP expression in tissues or cell lines, aiding studies on its oncogenic mechanisms or prognostic value.
Additionally, SSX2IP is critical in neuronal development, regulating axon guidance and synapse formation. Its dysfunction is linked to neurodevelopmental disorders. Commercially available SSX2IP antibodies are typically validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers utilize these to explore SSX2IP's dual roles in cancer progression and neural connectivity, offering insights into potential therapeutic targets. Ongoing studies focus on its signaling networks and tissue-specific functions across diseases.
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