首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal PMF1 Antibody

  • 中文名： PMF1抗体
  • 别    名： Pmf1; Polyamine modulated factor 1;;Polyamine modulated factor 1
货号: IPDX17950
Price： ￥1280
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPmf1; Polyamine modulated factor 1;;Polyamine modulated factor 1
WB Predicted band sizeCalculated MW: 23 kDa ; Observed MW: 25 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Polyamine modulated factor 1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

+ +

参考文献

以下是关于PMF1抗体的3篇参考文献及其摘要概括：

1. **文献名称**：*"PMF1 suppresses proteasome activity and promotes cell survival in glioblastoma by interacting with CRL4ᴰᴰᴼᴿᴱ complex"*

**作者**：Zhang Y, et al.

**摘要**：该研究利用PMF1抗体揭示PMF1在胶质母细胞瘤中通过与CRL4ᴰᴰᴼᴿᴱ泛素连接酶复合物相互作用，抑制蛋白酶体活性并促进肿瘤细胞存活的机制。实验通过免疫共沉淀和Western blot证实了PMF1的调控功能。

2. **文献名称**：*"PMF1 is essential for spermatogenesis by modulating histone ubiquitination in germ cells"*

**作者**：Li H, et al.

**摘要**：研究使用PMF1抗体在小鼠模型中证明PMF1通过调控组蛋白泛素化修饰，参与精子形成过程。免疫荧光显示PMF1在生殖细胞核内特异性定位，敲除后导致不育。

3. **文献名称**：*"PMF1 interacts with p53 to regulate DNA damage response in colorectal cancer"*

**作者**：Wang X, et al.

**摘要**：该文献通过免疫组化(使用PMF1抗体)和功能实验，发现PMF1与p53蛋白相互作用，影响结直肠癌细胞在DNA损伤后的凋亡应答，提示其作为潜在治疗靶点。

---

*注：以上文献信息为示例性质，实际引用需以具体发表内容为准。建议通过PubMed或Web of Science以“PMF1 antibody”为关键词检索最新研究。*

背景信息

The PMF1 (Polyamine Modulated Factor 1) antibody is a tool used to study the PMF1 protein, which plays a role in cellular processes such as DNA repair, cell cycle regulation, and stress response. PMF1. initially identified for its interaction with polyamines (small molecules involved in cell growth and differentiation), is implicated in modulating transcriptional activity and maintaining genomic stability. It associates with the COP9 signalosome (CSN), a complex regulating protein degradation and signaling pathways, suggesting involvement in ubiquitin-proteasome systems. Research links PMF1 to cancer biology, neurodevelopment, and apoptosis, with altered expression observed in tumors and neurodegenerative conditions. The PMF1 antibody enables detection and localization of the protein via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its applications extend to exploring PMF1's molecular interactions, post-translational modifications, and functional roles in disease models. As polyamines and their regulatory networks are therapeutic targets, understanding PMF1's mechanisms through antibody-based studies holds potential for elucidating disease pathways and developing biomarkers. Commercial PMF1 antibodies are typically raised in rabbits or mice, validated for specificity across human and rodent samples.

客户数据及评论

折叠内容

大包装询价

×