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Rabbit Monoclonal SA2 Antibody

  • 中文名: SA2抗体
  • 别    名: SA 2; SA-2; SA2; SCC3 homolog 2; SCC3B; stag2; Stromal antigen 2;;Cohesin subunit SA 2
货号: IPDX17795
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSA 2; SA-2; SA2; SCC3 homolog 2; SCC3B; stag2; Stromal antigen 2;;Cohesin subunit SA 2
WB Predicted band size141 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Cohesin subunit SA 2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于SA2抗体的3篇参考文献示例(注:文献为示例性内容,实际引用时请核实真实来源):

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1. **文献名称**: "STAG2 mutations alter cohesion proteins and chromosome segregation in bladder cancer"

**作者**: Solomon DA, et al.

**摘要**: 该研究利用特异性SA2抗体探究了STAG2基因突变在膀胱癌中的作用,发现突变导致粘连蛋白复合体功能异常,引发染色体不稳定性,促进肿瘤发展。

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2. **文献名称**: "Cohesin-SA2 deficiency drives aneuploidy and tumorigenesis in mice"

**作者**: Remeseiro S, et al.

**摘要**: 通过SA2抗体在小鼠模型中检测Cohesin复合体,发现SA2缺失导致染色体分离错误和基因组不稳定,揭示了其在抑制肿瘤发生中的关键作用。

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3. **文献名称**: "Antibody-based profiling of STAG2 expression in human cancers"

**作者**: Kim JS, et al.

**摘要**: 本研究开发了一种高特异性SA2单克隆抗体,用于检测多种癌症组织中STAG2蛋白的表达水平,发现其低表达与预后不良和化疗耐药性相关。

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(注:以上文献信息为虚拟示例,实际引用请通过学术数据库获取真实文献。)

背景信息

SA2 (STAG2), a core component of the cohesin complex, plays a critical role in maintaining sister chromatid cohesion during mitosis and meiosis, ensuring accurate chromosome segregation. The cohesin complex, composed of SMC1. SMC3. RAD21. and STAG subunits (STAG1/SA1 or STAG2/SA2), also regulates chromatin organization, DNA repair, and gene transcription. SA2 specifically stabilizes cohesin-DNA interactions and facilitates loop extrusion in chromatin architecture. Mutations or dysregulation of SA2 are implicated in genomic instability and cancer, including acute myeloid leukemia (AML), glioblastoma, and bladder cancer, where SA2 loss correlates with aneuploidy and poor prognosis. SA2 antibodies are essential tools for studying cohesin function, detecting protein expression in cells/tissues via techniques like Western blot, immunofluorescence, or ChIP-seq. They aid in exploring SA2's role in chromatin dynamics, mitotic regulation, and disease mechanisms. Research using SA2 antibodies has revealed its tissue-specific expression patterns and potential as a biomarker for cohesinopathies or therapeutic targeting in cohesion-deficient cancers.

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