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Rabbit Monoclonal PMP22 Antibody

  • 中文名： PMP22抗体
  • 别    名： CMT1A; CMT1E; DSS; GAS3; Growth Arrest Specific 3; HMSNIA; HNPP; Peripheral myelin protein 22; PMP22; Sp110; Trembler;;PMP22
货号: IPDX17747
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCMT1A; CMT1E; DSS; GAS3; Growth Arrest Specific 3; HMSNIA; HNPP; Peripheral myelin protein 22; PMP22; Sp110; Trembler;;PMP22
WB Predicted band sizeCalculated MW: 18 kDa ; Observed MW: 22 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenA synthesized peptide derived from human PMP22
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇与PMP22抗体相关的文献示例(文献信息为基于公开研究的虚构描述，实际文献需通过数据库验证)：

1. **《Autoantibodies to PMP22 in autoimmune neuropathies》**

- 作者：Gabib et al. (2022)

- 摘要：研究检测到吉兰-巴雷综合征(GBS)患者血清中存在抗PMP22自身抗体，提示其可能参与周围神经髓鞘的自身免疫攻击机制。

2. **《PMP22 antibody as a biomarker in Charcot-Marie-Tooth disease》**

- 作者：Saporta & Shy (2019)

- 摘要：探讨抗PMP22抗体在CMT1A亚型中的表达差异，发现抗体水平与疾病严重程度相关，可能辅助诊断和预后评估。

3. **《Targeting PMP22 with monoclonal antibodies in a rodent neuropathy model》**

- 作者：Fledrich et al. (2020)

- 摘要：开发靶向PMP22的单克隆抗体，在动物模型中验证其促进髓鞘再生和改善神经传导功能的作用，为治疗提供新思路。

**注**：以上文献名为示例性质，具体内容需通过PubMed或Google Scholar检索真实文献(关键词：PMP22 antibody, autoimmune neuropathy, CMT)。实际研究中，PMP22相关文献更多聚焦基因突变(如CMT1A)而非抗体，抗PMP22抗体的研究相对较少。

背景信息

The PMP22 (Peripheral Myelin Protein 22) antibody is primarily used to detect and study the PMP22 protein, a key component of peripheral nerve myelin. Encoded by the PMP22 gene, this protein plays a critical role in the formation, stability, and maintenance of myelin sheaths around peripheral nerves. Mutations or dysregulation of PMP22 are linked to hereditary neuropathies, including Charcot-Marie-Tooth disease type 1A (CMT1A) and Hereditary Neuropathy with Liability to Pressure Palsies (HNPP). Antibodies targeting PMP22 are essential tools in neuroscience research, enabling the investigation of protein expression, localization, and function in both healthy and diseased states. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze tissue samples, cell cultures, or animal models. Clinically, PMP22 antibodies may aid in diagnosing neuropathies by identifying abnormal protein levels or pathological aggregates. Recent therapeutic strategies also explore monoclonal antibodies to modulate PMP22 expression or interactions, potentially addressing overproduction in CMT1A. However, challenges persist, including the protein's complex transmembrane structure, low immunogenicity, and the blood-nerve barrier limiting therapeutic antibody delivery. Ongoing research aims to refine antibody specificity and develop delivery systems to enhance their diagnostic and therapeutic potential in peripheral neuropathies.

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