| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ascites sialoglycoprotein 1; Ascites sialoglycoprotein 2; Ascites sialoglycoprotein; ASGP; ASGP-1; ASGP-2; Muc4; Mucin 4 cell surface associated; Mucin 4 tracheobronchial; Mucin-4 beta chain; Testis mucin;;Mucin 4 |
| WB Predicted band size | Calculated MW: 542 kDa ; Observed MW: 120 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Mucin 4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3-4篇关于MUC4抗体的参考文献示例(注：以下信息基于公开研究领域的一般性描述，具体文献需根据实际数据库核实)：
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1. **文献名称**：*MUC4 overexpression in pancreatic cancer: prognostic significance and therapeutic implications*
**作者**：Choudhury A, et al.
**摘要**：研究通过免疫组化(使用MUC4特异性抗体)发现MUC4在胰腺癌组织中高表达，且与患者生存率降低相关，提示其可作为预后标志物及潜在治疗靶点。
2. **文献名称**：*MUC4 as a diagnostic biomarker in breast cancer: validation via monoclonal antibody-based assays*
**作者**：Singh AP, Hollingsworth MA
**摘要**：开发了针对MUC4的单克隆抗体，并验证其在乳腺癌组织中的特异性结合能力，表明MUC4表达与肿瘤侵袭性及转移风险升高相关。
3. **文献名称**：*Targeting MUC4 in ovarian cancer with a novel monoclonal antibody-drug conjugate*
**作者**：Carraway KL, et al.
**摘要**：研究报道了一种新型MUC4抗体-药物偶联物(ADC)，在卵巢癌细胞系及小鼠模型中显示出显著抑制肿瘤生长的效果，提示其靶向治疗潜力。
4. **文献名称**：*MUC4-mediated resistance to chemotherapy in colorectal cancer: mechanistic insights*
**作者**：Bafna S, et al.
**摘要**：通过MUC4抗体阻断实验，发现MUC4通过激活HER2/EGFR信号通路增强结直肠癌细胞对化疗的耐药性，为逆转耐药性提供理论依据。
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建议通过PubMed或Google Scholar搜索具体文献标题及作者以获取全文。
**Background of MUC4 Antibodies**
MUC4. a transmembrane glycoprotein encoded by the *MUC4* gene, belongs to the mucin family, which plays critical roles in epithelial protection, lubrication, and cell signaling. Unlike secreted mucins, MUC4 is anchored to the cell membrane and is characterized by its large extracellular domain rich in tandem repeats of serine and threonine residues, which undergo extensive O-glycosylation. Dysregulation of MUC4 has been implicated in various cancers, including pancreatic, ovarian, breast, and lung carcinomas, where its overexpression correlates with tumor progression, metastasis, and poor prognosis.
MUC4 antibodies are essential tools for studying its biological functions and clinical relevance. These antibodies target specific epitopes on the MUC4 protein, enabling its detection in tissues, cell lines, or biological fluids via techniques like immunohistochemistry (IHC), Western blotting, or flow cytometry. Monoclonal antibodies (mAbs) are particularly valuable due to their high specificity, while polyclonal antibodies offer broader epitope recognition.
Clinically, MUC4 antibodies are explored for diagnostic applications, such as identifying cancer biomarkers, and therapeutic development, including antibody-drug conjugates (ADCs) or immune-targeted therapies. Challenges remain in targeting MUC4 due to its structural complexity, heterogeneous glycosylation patterns across tissues, and potential cross-reactivity with other mucins. Ongoing research aims to refine antibody specificity and evaluate their utility in personalized oncology, positioning MUC4 as a promising but challenging target in cancer research and therapy.
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