| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | hITF; hP1.B; Intestinal trefoil factor; ITF; mITF; P1B; Polypeptide P1.B; TFF3; TFI; TREFOIL; Trefoil factor 3;;Trefoil factor 3 |
| WB Predicted band size | 9 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Trefoil factor 3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Trefoil Factor 3(TFF3)抗体的3篇参考文献概览：
1. **"Trefoil factor family 3 as a potential prognostic biomarker and therapeutic target for gastric cancer"**
*作者：Chen et al.*
摘要：研究探讨TFF3在胃癌组织中的高表达及其与患者预后的关联，利用TFF3抗体进行免疫组化分析，表明TFF3可能作为胃癌诊断标志物和治疗靶点。
2. **"Antibody-based detection of TFF3 in colorectal cancer: implications for early diagnosis"**
*作者：Smith et al.*
摘要：开发了一种高特异性TFF3单克隆抗体，用于ELISA检测结直肠癌患者血清TFF3水平，证实其作为早期筛查工具的潜力。
3. **"Trefoil factor 3 promotes mucosal repair via interaction with the EGFR pathway: insights from antibody-blockade experiments"**
*作者：Tanaka et al.*
摘要：通过TFF3中和抗体阻断实验，揭示TFF3通过激活EGFR通路促进肠道黏膜修复的分子机制，为炎症性肠病治疗提供新思路。
注：以上文献信息为示例，实际引用需核对真实出版物。如需具体文章，建议在PubMed或Google Scholar检索关键词“TFF3 antibody”“TFF3 biomarker”等。
Trefoil Factor 3 (TFF3) is a small secretory protein belonging to the trefoil factor family, characterized by a conserved three-loop "trefoil" domain stabilized by disulfide bonds. Primarily expressed in intestinal goblet cells and respiratory epithelia, TFF3 plays critical roles in mucosal protection, repair, and regeneration by promoting cell migration, reducing apoptosis, and modulating inflammation. It is also implicated in maintaining epithelial barrier integrity and interacting with signaling pathways such as EGFR and Wnt. Dysregulation of TFF3 has been linked to gastrointestinal cancers, inflammatory bowel disease (IBD), and chronic respiratory conditions, where its expression often correlates with disease progression or healing.
TFF3 antibodies are essential tools for detecting and quantifying TFF3 in research and diagnostics. These antibodies, typically developed in rabbits or mice, target specific epitopes of TFF3 and are used in techniques like Western blotting, immunohistochemistry (IHC), and ELISA. High-quality TFF3 antibodies exhibit high specificity and sensitivity, enabling precise localization in tissues or accurate measurement in biological fluids. Clinically, TFF3 antibodies aid in studying its role as a biomarker for gastrointestinal cancers or monitoring IBD treatment responses. Recent studies also explore TFF3's therapeutic potential, with antibodies helping to validate its mechanisms in preclinical models. Reliable TFF3 antibodies thus bridge basic research and clinical applications, offering insights into mucosal health and disease.
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