| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CMT2M; CMTDI1; CMTDIB; DI CMTB; Dnm2; DYN II; DYN2; Dynamin II; Dynamin2; DynaminII; DYNII;;Dynamin 2 |
| WB Predicted band size | 98 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Dynamin 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Dynamin2抗体的3篇参考文献(信息基于公开文献概括，非真实引用)：
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1. **标题**: "Dynamin2 GTPase regulates cytoskeletal dynamics in neuronal development"
**作者**: Smith J, et al.
**摘要**: 研究利用特异性Dynamin2抗体，揭示其在神经元轴突形成中的作用，证明Dynamin2通过调控微管稳定性影响突触可塑性。
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2. **标题**: "A novel monoclonal antibody targeting Dynamin2 inhibits cancer cell invasion"
**作者**: Lee H, et al.
**摘要**: 开发了一种高特异性抗Dynamin2单克隆抗体，实验显示其通过阻断Dynamin2介导的膜重塑过程，显著抑制肿瘤细胞的迁移和侵袭能力。
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3. **标题**: "Dynamin2 mutations and antibody-based detection in centronuclear myopathy"
**作者**: Garcia-Rojas M, et al.
**摘要**: 通过免疫组化结合定制Dynamin2抗体，在遗传性肌病患者中鉴定出Dynamin2突变蛋白异常聚集，为疾病诊断提供分子标志物。
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(注：以上为示例性内容，实际文献需通过PubMed等数据库检索确认。)
Dynamin 2 (DNM2) is a large GTPase enzyme critical for membrane remodeling processes, including clathrin-mediated endocytosis, intracellular vesicle trafficking, and organelle division. As a member of the dynamin superfamily, it self-assembles into helical structures at membrane necks to mediate membrane fission through GTP-dependent conformational changes. DNM2 is ubiquitously expressed and interacts with multiple partners, such as endophilin and sorting nexins, to regulate cellular dynamics. Mutations in the *DNM2* gene are linked to human disorders like centronuclear myopathy (CNM) and Charcot-Marie-Tooth neuropathy (CMT), highlighting its physiological importance.
Dynamin 2 antibodies are essential tools for studying its expression, localization, and function. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate DNM2’s role in cellular processes or disease mechanisms. For instance, researchers employ them to analyze DNM2 dysregulation in cancer metastasis, synaptic vesicle recycling in neurons, or abnormal membrane trafficking in genetic disorders. Monoclonal and polyclonal variants targeting specific domains (e.g., the GTPase or pleckstrin homology domains) help dissect structure-function relationships. Validation via knockout controls or siRNA knockdown ensures antibody specificity. Commercially available antibodies often include data on cross-reactivity and species compatibility, aiding experimental design. Reliable DNM2 antibodies are pivotal for advancing research in cell biology, neurobiology, and genetic disease therapeutics.
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