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Rabbit Monoclonal SNAP23 Antibody

  • 中文名： SNAP23抗体
  • 别    名： HsT17016; LS-B8340; SNAP23A; SNAP23B; Synaptosomal associated protein 23; Vesicle membrane fusion protein SNAP23;;SNAP23
货号: IPDX17710
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHsT17016; LS-B8340; SNAP23A; SNAP23B; Synaptosomal associated protein 23; Vesicle membrane fusion protein SNAP23;;SNAP23
WB Predicted band size23 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human SNAP23
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于SNAP23抗体的3篇文献示例(内容基于公开研究整理，非真实引用)：

1. **文献名称**：*SNAP23 regulates phagocytosis in macrophages by mediating vesicle fusion*

**作者**：Smith A, et al.

**摘要**：该研究利用SNAP23抗体进行免疫印迹和免疫荧光分析，发现SNAP23在巨噬细胞吞噬过程中调控囊泡与质膜融合，影响病原体清除能力。

2. **文献名称**：*Role of SNAP23 in insulin-stimulated GLUT4 translocation in adipocytes*

**作者**：Chen L, et al.

**摘要**：通过SNAP23抗体敲低和共聚焦显微镜观察，证明SNAP23参与胰岛素诱导的GLUT4囊泡转运至细胞膜的过程，为代谢疾病研究提供依据。

3. **文献名称**：*SNAP23 isoforms differentially regulate cancer exosome release*

**作者**：Wang Y, et al.

**摘要**：研究使用SNAP23特异性抗体区分两种亚型，发现SNAP23b通过促进多囊泡体与质膜融合，驱动肿瘤外泌体分泌，影响肿瘤微环境。

(注：以上文献为示例，实际引用时需核实真实文献来源。)

背景信息

SNAP-23 (Synaptosome-associated protein of 23 kDa) is a member of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family, which mediates membrane fusion events in intracellular trafficking and exocytosis. Unlike its homolog SNAP-25. SNAP-23 is ubiquitously expressed and plays a critical role in diverse secretory pathways, including vesicle docking, neurotransmitter release, and plasma membrane repair. It interacts with syntaxin and synaptotagmin proteins to facilitate vesicle-membrane fusion. Antibodies targeting SNAP-23 are widely used to study its localization, expression, and function in cellular processes such as immune cell activation, hormone secretion, and cancer metastasis. These antibodies are essential tools in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore SNAP-23's involvement in diseases like cancer, inflammation, and metabolic disorders. Researchers also utilize SNAP-23 antibodies to investigate its role in pathological conditions characterized by aberrant membrane trafficking, such as neutrophil degranulation or tumor-derived microvesicle release. Commercial SNAP-23 antibodies are typically validated for specificity, often distinguishing between SNAP-23 and SNAP-25 isoforms. Studies using these reagents have highlighted SNAP-23's dual regulatory roles in both constitutive and regulated exocytosis, making it a key focus in cell biology and therapeutic research.

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