| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Antigen CD42b alpha; BDPLT1; BDPLT3; BSS; CD42b alpha; DBPLT3; Glycoprotein Ibalpha; GP Ib alpha; GP1B; GP1BA; GPIb alpha; GPIbA; VWDP;;Glycoprotein Ibalpha |
| WB Predicted band size | Calculated MW: 72 kDa ; Observed MW: 143 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Glycoprotein Ibalpha |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于CD42b抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库查询)：
1. **文献名称**: "Structural and functional analysis of the platelet glycoprotein Ib-IX-V complex"
**作者**: Berndt MC, Andrews RK
**摘要**: 该研究解析了CD42b(GP Ibα)作为血小板膜糖蛋白Ib-IX-V复合物的关键组分，在血管损伤后与von Willebrand因子结合并介导血小板黏附的分子机制，揭示了其结构功能与相关出血性疾病的关系。
2. **文献名称**: "Platelet glycoprotein Ibα as a biomarker for thrombotic disorders"
**作者**: Michelson AD, et al.
**摘要**: 本文探讨了CD42b抗体在诊断遗传性血小板功能障碍(如Bernard-Soulier综合征)中的应用，并评估其作为血栓性疾病生物标志物的潜力，强调了其在流式细胞术检测中的特异性。
3. **文献名称**: "CD42b-mediated signaling in platelet activation and thrombosis"
**作者**: Shattil SJ, et al.
**摘要**: 研究聚焦CD42b抗体对血小板信号通路的调控作用，发现其与钙离子内流、PI3K/Akt通路激活的关联，为抗CD42b靶向药物治疗动脉血栓提供了理论依据。
建议通过PubMed或Web of Science检索实际文献，使用关键词“CD42b antibody”或“GP1BA antibody”获取最新研究。
CD42b, also known as glycoprotein Ibα (GPIbα), is a subunit of the platelet surface membrane glycoprotein Ib-IX-V complex, which plays a critical role in platelet adhesion and thrombus formation. This receptor binds von Willebrand factor (VWF) under high shear stress, initiating platelet attachment to damaged vascular endothelium. The CD42b antibody specifically targets the GPIbα subunit, enabling the identification and analysis of platelets in research and clinical diagnostics.
CD42b antibodies are widely used in flow cytometry to assess platelet count, activation status, and function. They are also employed in immunoassays to study inherited platelet disorders like Bernard-Soulier syndrome, characterized by mutations in the *GP1BA* gene leading to reduced or dysfunctional CD42b expression. Additionally, these antibodies aid in investigating thrombotic and bleeding disorders, as well as monitoring platelet-related responses in cardiovascular diseases. Recent studies explore their potential in targeting platelet-derived microvesicles or inhibiting pathological thrombus formation. Due to their specificity, CD42b antibodies remain essential tools in hematology research and diagnostic workflows.
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