关键信息
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基因名
INPP5A
- 应用
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别名
4; 43 kDa inositol polyphosphate 5-phophatase; 5-trisphosphate 5-phosphatase; 5PTase; CTCL tumor antigen HD-CL-02; DKFZp434A1721; I5P1; I5P1_HUMAN; Inositol polyphosphate 5 phosphatase; inositol polyphosphate-5-phosphatase A; inositol trisphosphate-5-phosphatase; INPP5A; INPP5A inositol polyphosphate-5-phosphatase; InsP3 5-phosphatase; MGC116947; MGC116949; Type I inositol-1; type I inositol-1,4,5-trisphosphate 5-phophatase
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14642
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表达区间
1-409aa
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分子量
63.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
INPP5A (Inositol Polyphosphate Phosphatase A) is an important enzyme involved in the phosphoinositide signaling pathway, which plays a critical role in various cellular processes, including cell growth, differentiation, and metabolism. Research has increasingly focused on exploring the functional implications of INPP5A due to its involvement in regulating intracellular calcium levels and its potential role in cancer biology and neurodegenerative diseases. Elevated levels of INPP5A have been associated with tumor progression and poor prognosis in several cancer types, highlighting its potential as a therapeutic target. Moreover, the recruitment of INPP5A to specific cellular membranes and its interaction with other signaling molecules suggest that this enzyme could serve as a crucial regulator of cellular signaling networks. The study of recombinant INPP5A protein is vital for understanding its biochemical properties, interactions, and physiological functions in detail. By producing and purifying INPP5A in a recombinant system, researchers can investigate its enzymatic activity, structural characteristics, and dynamic regulation in response to different stimuli. This knowledge may lead to the development of novel therapeutic strategies aimed at modulating INPP5A activity to treat various diseases, particularly those where dysregulation of phosphoinositide signaling is implicated. Overall, INPP5A represents a significant focus in cellular signaling research, and its recombinant protein studies hold promise for advancing our understanding of its role in health and disease.
