| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ly-6A.2/Ly-6E.1; Ly6a; Ly6al; Lymphocyte antigen 6A-2/6E-1; Lymphocyte antigen Ly 6A.2/Ly 6E.1; SCA-1; Stem cell antigen 1; T cell activating protein; TAP; ;Ly6a |
| WB Predicted band size | Calculated MW: 14 kDa ; Observed MW: 18 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | A synthesized peptide derived from mouse Ly6a |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于LY6A抗体的参考文献示例(注：以下为假设性示例，实际文献需通过学术数据库查询确认)：
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1. **文献名称**：*LY6A/SCA-1 as a Biomarker for Murine Hematopoietic Stem Cell Enrichment*
**作者**：Dykstra B, et al.
**摘要**：研究使用LY6A抗体通过流式细胞术分选小鼠造血干细胞，证实LY6A是高效富集功能性干细胞的表面标志物，并探讨其在干细胞自我更新中的作用。
2. **文献名称**：*LY6A-Mediated Immune Regulation in Tumor Microenvironments*
**作者**：Zhang L, et al.
**摘要**：通过LY6A抗体阻断实验，揭示LY6A在肿瘤微环境中抑制T细胞活化的机制，提示其作为免疫治疗潜在靶点的可能性。
3. **文献名称**：*SCA-1+ Progenitors in Cardiac Regeneration: Role of LY6A Antibody-Based Tracking*
**作者**：Oh H, et al.
**摘要**：利用LY6A抗体标记心脏祖细胞，证明其在心肌损伤修复中的再生潜力，为心血管疾病治疗提供新思路。
4. **文献名称**：*Interferon-Inducible LY6A as a Restriction Factor for Viral Entry*
**作者**：Wei J, et al.
**摘要**：研究发现LY6A在干扰素诱导下抑制病毒进入宿主细胞，通过抗体阻断实验验证其抗病毒功能，提示其作为广谱抗病毒靶点的潜力。
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如需真实文献，建议通过PubMed、Google Scholar等平台以关键词“LY6A antibody”“SCA-1”或“LY6A function”检索近期研究。
LY6A antibody targets the LY6A protein, a member of the Ly-6/urokinase-type plasminogen activator receptor (uPAR) superfamily. LY6A, also known as stem cell antigen-1 (Sca-1) in mice, is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein primarily expressed in hematopoietic stem cells (HSCs), progenitor cells, and certain immune cells. It plays roles in cell adhesion, signaling, and immune regulation. LY6A antibodies are widely used in research to identify and isolate stem cell populations, particularly in murine models, aiding studies on hematopoiesis, cancer stem cells, and tissue regeneration.
First characterized in the 1980s, LY6A gained prominence as a marker for murine HSCs due to its selective expression in these cells. Its human homolog, LY6A (or LY6K), shares structural similarities but differs in expression patterns and functional roles. LY6A antibodies, often monoclonal (e.g., clone D7 or E13-161.7), enable flow cytometry, immunofluorescence, and cell sorting applications. Recent studies also link LY6A to tumor progression and immune evasion, expanding its relevance in oncology. However, species-specific differences necessitate careful antibody selection. Despite its utility, LY6A's precise molecular mechanisms remain under investigation, particularly its interplay with signaling pathways like Wnt and Notch. This antibody remains a cornerstone tool in stem cell and immunology research.
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