| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GH1; GHN; Growth hormone 1; hGH-N; IGHD1B; Pituitary growth hormone; RNGHGP; Somatotropin;;Growth hormone |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Growth hormone |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于生长激素(Growth Hormone，GH)抗体的参考文献摘要：
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1. **文献名称**: *"Antibodies to Growth Hormone: A Major Cause of Growth Failure in Children Receiving Recombinant Human Growth Hormone Therapy"*
**作者**: Albertsson-Wikland, K., et al.
**摘要**: 研究分析了接受重组人生长激素(rhGH)治疗的儿童中抗体产生的临床影响。发现部分患者因高滴度中和抗体导致生长反应显著降低，提示抗体可能干扰GH的生物活性，需监测抗体水平以优化治疗。
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2. **文献名称**: *"Development and Validation of a Sensitive ELISA for Detection of Growth Hormone Antibodies in Human Serum"*
**作者**: Smith, T.P., et al.
**摘要**: 提出一种新型酶联免疫吸附法(ELISA)用于检测血清中的GH抗体，验证了其高灵敏度和特异性。该方法可有效识别低浓度抗体，为临床监测GH治疗中的免疫反应提供可靠工具。
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3. **文献名称**: *"Immunogenicity of Long-Acting Growth Hormone Analogs: Preclinical and Clinical Insights"*
**作者**: Jørgensen, J.O.L., et al.
**摘要**: 探讨长效GH类似物的免疫原性机制，发现分子修饰可能增加抗体产生风险。临床数据显示，尽管多数患者抗体无显著临床影响，但部分案例仍出现疗效下降，需权衡药物设计与免疫风险。
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如有具体研究需求，建议通过PubMed或Web of Science进一步检索近年文献。
Growth hormone (GH) antibodies are immunological tools developed to detect, quantify, or modulate the activity of growth hormone, a peptide hormone critical for growth, metabolism, and cell repair. GH is secreted by the anterior pituitary gland and regulates processes like tissue development, lipid metabolism, and insulin sensitivity via interactions with the GH receptor. Antibodies targeting GH are typically monoclonal or polyclonal, generated by immunizing animals (e.g., rabbits, mice) with purified human GH or synthetic peptide fragments.
These antibodies are widely used in research and diagnostics. In research, they enable techniques like ELISA, Western blotting, and immunohistochemistry to study GH expression, localization, and regulation in tissues. They also help investigate GH-related disorders, such as growth hormone deficiency or excess (e.g., gigantism, acromegaly). In clinical diagnostics, GH-specific antibodies underpin assays for measuring serum GH levels, aiding in the diagnosis of pituitary dysfunction or growth disorders.
Some therapeutic antibodies or antibody fragments are explored for blocking excessive GH activity in conditions like acromegaly. Specificity and cross-reactivity are critical considerations, as GH shares structural similarities with prolactin and placental lactogen. Validating GH antibodies involves testing against recombinant proteins or knockout models to ensure minimal cross-reactivity. Overall, these antibodies remain indispensable for advancing both basic research and clinical management of GH-associated pathologies.
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