Rabbit Monoclonal TLR5 Antibody

Toll-like receptor 5 (TLR5) is a transmembrane pattern-recognition receptor that plays a critical role in innate immunity by detecting bacterial flagellin. Upon activation, TLR5 triggers signaling cascades involving NF-κB and MAPK pathways, leading to pro-inflammatory cytokine production and antimicrobial responses. TLR5 antibodies, either agonistic or antagonistic, are essential tools for studying TLR5-mediated immune regulation, host-pathogen interactions, and therapeutic targeting. Agonistic antibodies mimic flagellin to stimulate TLR5. potentially enhancing immune responses against infections or cancer. Antagonistic antibodies block TLR5 signaling, offering potential therapies for inflammatory diseases, autoimmune disorders, or sepsis caused by excessive TLR5 activation. Research also explores TLR5's dual role in cancer progression, where it may promote tumorigenesis in certain contexts (e.g., gastrointestinal cancers) or exert antitumor effects by activating immune surveillance. TLR5 antibodies are widely used in immunoassays (e.g., flow cytometry, Western blot) to detect receptor expression in immune cells, epithelial tissues, and tumor microenvironments. Recent studies investigate engineered TLR5 antibodies for targeted drug delivery or vaccine adjuvants. However, challenges remain in balancing therapeutic efficacy with off-target effects due to TLR5's broad tissue distribution. Ongoing research aims to optimize specificity and clinical applicability.