| WB | 1/1000-1/5000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | I 1; I1; Inhibitor 1; IPP1; Ppp1r1a; Protein phosphatase 1 regulatory (inhibitor) subunit 1A;;PPP1R1A |
| WB Predicted band size | Calculated MW: 19 kDa ; Observed MW: 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human PPP1R1A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于PPP1R1A抗体的模拟参考文献示例(注：以下为构建示例，非真实文献，仅供格式参考)：
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1. **文献名称**: *PPP1R1A expression in hepatocellular carcinoma: Correlation with clinical prognosis*
**作者**: Zhang L, et al.
**摘要**: 本研究通过免疫组化分析PPP1R1A在肝细胞癌组织中的表达，发现其高表达与患者不良预后相关。抗体(货号：ABX-123)用于验证PPP1R1A蛋白水平，并揭示其通过调节PP1活性影响癌细胞增殖的机制。
2. **文献名称**: *Role of PPP1R1A in cAMP-dependent signaling in neuronal cells*
**作者**: Smith J, et al.
**摘要**: 利用PPP1R1A特异性抗体(克隆号：1A3B2)进行Western blot和免疫荧光实验，证明PPP1R1A在小鼠神经元中调控cAMP信号通路，影响突触可塑性及学习记忆功能。
3. **文献名称**: *Validation of a novel PPP1R1A monoclonal antibody for pancreatic cancer research*
**作者**: Chen H, et al.
**摘要**: 研究报道了一种新型抗PPP1R1A单克隆抗体的开发与验证，通过免疫沉淀和质谱分析确认其特异性，并应用于胰腺癌模型，揭示PPP1R1A在肿瘤代谢重编程中的作用。
4. **文献名称**: *PPP1R1A as a biomarker in breast cancer: Insights from immunohistochemical analysis*
**作者**: Patel S, et al.
**摘要**: 使用商业化PPP1R1A抗体(品牌：BioSci)对乳腺癌组织芯片分析，发现PPP1R1A低表达与雌激素受体阳性亚型相关，提示其作为潜在治疗靶点的可能性。
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**注意**：以上文献为示例性质，实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实文献，并核对抗体货号及研究内容。
The PPP1R1A antibody is a tool used to detect the Protein Phosphatase 1 Regulatory Inhibitor Subunit 1A (PPP1R1A), a key regulatory protein involved in modulating the activity of Protein Phosphatase 1 (PP1). PP1 is a serine/threonine phosphatase critical for diverse cellular processes, including cell cycle progression, metabolic regulation, and signal transduction. PPP1R1A acts as an inhibitory subunit that binds to PP1. fine-tuning its phosphatase activity in a tissue-specific manner. This regulatory interaction impacts pathways such as glycogen metabolism, muscle contraction, and neuronal signaling.
Antibodies targeting PPP1R1A are widely utilized in research to study its expression, localization, and functional roles in physiological and pathological contexts. They are commonly applied in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies have linked PPP1R1A dysregulation to diseases such as cancer, where altered expression may influence tumor progression, metastasis, or therapeutic resistance. Additionally, its role in metabolic disorders and neurodegenerative conditions is under investigation.
These antibodies are typically produced in hosts like rabbits or mice, with validation steps including knockout controls to confirm specificity. Researchers rely on PPP1R1A antibodies to explore its regulatory mechanisms, offering insights into cellular homeostasis and potential therapeutic targets.
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