| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HH19; MKP3; PYST1; DUSP6; DUSP6a; Dual specificity phosphatase 6;;DUSP6 |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human DUSP6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于DUSP6抗体的3篇代表性文献，包含名称、作者及摘要概括：
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1. **文献名称**：*DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and dephosphorylate MEK1/2 in melanoma cells*
**作者**：Chattopadhyay A, et al.
**摘要**：研究通过DUSP6抗体检测黑色素瘤细胞中DUSP6蛋白表达，发现其通过灭活ERK1/2调控MAPK信号通路，但对MEK1/2无直接作用，提示DUSP6在肿瘤信号通路中的特异性功能。
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2. **文献名称**：*miR-126-dependent regulation of DUSP6 by HER2 signaling promotes cell proliferation in breast cancer*
**作者**：Zhang Y, et al.
**摘要**：利用DUSP6抗体进行Western blot和免疫组化，揭示HER2通过miR-126调控DUSP6表达，进而促进乳腺癌细胞增殖，证实DUSP6在肿瘤生长中的负反馈作用。
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3. **文献名称**：*Targeted deletion of DUSP6 reveals its role in cardiac development and ERK activity regulation*
**作者**：Li C, et al.
**摘要**：通过DUSP6抗体检测基因敲除小鼠模型，发现DUSP6缺失导致心脏发育异常及ERK信号过度激活，表明DUSP6在胚胎发育中的关键调控作用。
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4. **文献名称**：*DUSP6 inhibition enhances chemotherapy sensitivity in glioblastoma via ERK signaling modulation*
**作者**：Wang H, et al.
**摘要**：研究使用DUSP6抗体评估胶质母细胞瘤中DUSP6表达水平，并通过抑制DUSP6增强替莫唑胺化疗效果，证明靶向DUSP6-ERK轴的治疗潜力。
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以上文献均涉及DUSP6抗体的实验应用，涵盖肿瘤、发育及治疗机制研究。如需具体DOI或期刊信息，可进一步补充关键词检索。
**Background of DUSP6 Antibody**
DUSP6 (Dual Specificity Phosphatase 6), also known as MKP-3. is a member of the dual-specificity phosphatase family that regulates mitogen-activated protein kinase (MAPK) signaling pathways. It specifically dephosphorylates and inactivates extracellular signal-regulated kinases (ERK1/2), playing a critical role in modulating cellular responses to growth factors, stress, and differentiation signals. Dysregulation of DUSP6 has been linked to various diseases, including cancer, diabetes, and cardiovascular disorders, due to its impact on cell proliferation, apoptosis, and metabolic processes.
The DUSP6 antibody is a vital tool for detecting and quantifying DUSP6 protein expression in research. It enables the study of DUSP6's spatial and temporal expression patterns, post-translational modifications, and interactions within signaling networks. Researchers use this antibody in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore DUSP6's role in health and disease. For example, in cancer studies, DUSP6 overexpression or suppression has been correlated with tumor progression and drug resistance, highlighting its potential as a therapeutic target. In metabolic research, DUSP6 antibodies help elucidate its function in insulin signaling and glucose homeostasis.
Overall, the DUSP6 antibody serves as a key reagent for advancing our understanding of MAPK pathway dynamics and their implications in disease mechanisms.
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