| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TSPO; PBR; BZRP; IBP; MBR; PKBS; Mitochondrial benzodiazepine receptor; Peripheral benzodiazepine receptor;;TSPO |
| WB Predicted band size | Calculated MW: 19 kDa ; Observed MW: 18 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human TSPO |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇与PBR(TSPO)抗体相关的文献摘要概括：
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1. **文献名称**：*The role of translocator protein in neurodegenerative disease*
**作者**：Chen, M.K., Guilarte, T.R.
**摘要**：探讨TSPO抗体在小胶质细胞活化检测中的应用，通过免疫组化和PET成像揭示其与阿尔茨海默病、帕金森病中神经炎症的关联。
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2. **文献名称**：*Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function*
**作者**：Papadopoulos, V., et al.
**摘要**：提出TSPO的标准化命名，并综述其抗体在胆固醇转运、类固醇合成研究中的关键作用，强调抗体在定位线粒体功能中的工具价值。
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3. **文献名称**：*TSPO antibodies for cancer theranostics*
**作者**：Gatliff, J., Campanella, M.
**摘要**：报道新型抗TSPO单克隆抗体的开发，验证其在肿瘤细胞线粒体膜定位的特异性，探索其用于癌症靶向治疗和分子影像的潜力。
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(注：以上为示例性概括，实际文献需通过PubMed等数据库检索确认。)
PBR (Peripheral Benzodiazepine Receptor) antibodies target a mitochondrial outer membrane protein initially identified for its ability to bind benzodiazepines, distinct from central nervous system receptors. Now renamed Translocator Protein (TSPO), this 18 kDa molecule plays critical roles in cholesterol transport for steroidogenesis, mitochondrial function, and cellular stress responses. PBR/TSPO is highly expressed in steroid-producing tissues (e.g., adrenal glands) and activated microglia, making it a biomarker for neuroinflammatory conditions like Alzheimer's and multiple sclerosis.
Research using PBR antibodies has revealed its involvement in pathological processes, including neurodegeneration, cancer progression, and psychiatric disorders. In neuroimaging, TSPO-targeted radioligands (e.g., PK11195) enable visualization of neuroinflammation through PET scans. However, antibody-based studies face challenges due to TSPO's structural heterogeneity across species and polymorphism-induced ligand-binding variations in humans (e.g., rs6971 SNP). Recent efforts focus on developing isoform-specific antibodies and second-generation ligands with improved specificity.
These tools continue to advance our understanding of TSPO's dual roles in physiological homeostasis and disease mechanisms, particularly in glial activation dynamics and mitochondrial dysfunction pathways.
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