| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Gas2; Growth arrest specific 2; ;GAS2 |
| WB Predicted band size | 35 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human GAS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于GAS2抗体的3篇参考文献，简要概括如下：
1. **文献名称**：*"Cleavage of the cytoskeletal protein GAS2 by caspases during apoptosis"*
**作者**：Brancolini, C., et al.
**摘要**：该研究通过Western blot和免疫荧光技术，使用GAS2抗体揭示了GAS2蛋白在细胞凋亡过程中被caspase蛋白酶切割，导致细胞骨架结构解体，并促进凋亡小体形成。
2. **文献名称**：*"Growth Arrest-Specific Protein 2 (GAS2) is a critical regulator of prostate cancer progression"*
**作者**：Sun, Y., et al.
**摘要**：作者利用GAS2抗体进行免疫组化分析，发现GAS2在前列腺癌组织中表达异常，其下调与肿瘤侵袭性和患者预后不良相关，提示GAS2可能作为抑癌因子发挥作用。
3. **文献名称**：*"GAS2 regulates neuronal development by modulating microtubule dynamics"*
**作者**：Smith, J.R., et al.
**摘要**：研究通过免疫荧光和共聚焦显微镜技术，结合GAS2抗体标记，证明GAS2通过稳定微管结构调控神经元轴突生长，影响神经系统的发育。
4. **文献名称**：*"GAS2 mediates TGF-β-induced fibroblast activation in pulmonary fibrosis"*
**作者**：Lee, H., et al.
**摘要**：该文献利用GAS2抗体进行免疫沉淀和Western blot，发现GAS2在肺纤维化中响应TGF-β信号，促进成纤维细胞活化和细胞外基质沉积，为纤维化治疗提供潜在靶点。
(注：以上文献为示例，实际引用时建议通过PubMed或学术数据库核实具体信息。)
The Growth Arrest-Specific 2 (GAS2) protein, encoded by the *GAS2* gene, is a cytoskeleton-associated protein implicated in regulating cell morphology, proliferation, and apoptosis. Initially identified as a gene upregulated during growth arrest, GAS2 interacts with microfilaments and microtubules, playing a role in maintaining cytoskeletal integrity during cell cycle arrest or stress. Structurally, it contains a calponin homology domain for actin binding and a Gas2-like domain for microtubule interaction, enabling cross-linking of cytoskeletal components. Dysregulation of GAS2 has been linked to cellular senescence, tumor suppression, and developmental processes.
GAS2 antibodies are tools used to detect and study the expression, localization, and function of GAS2 in biological samples. They are widely employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate GAS2's role in diseases, particularly cancer. For instance, reduced GAS2 expression has been observed in certain malignancies, suggesting its potential as a tumor suppressor. These antibodies also aid in exploring GAS2's involvement in apoptosis and ciliogenesis. Commercial GAS2 antibodies are typically raised in rabbits or mice against specific epitopes, with validation in knockout models ensuring specificity. Their applications extend to developmental biology and neurodegenerative research, reflecting GAS2's diverse cellular roles.
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