| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TFQTL1; TF; TRFE; Transferrin; Serotransferrin; Serotransferrin;;Transferrin |
| WB Predicted band size | 77 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Transferrin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于转铁蛋白抗体(Transferrin Antibody)的虚构参考文献示例，供参考：
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1. **文献名称**: *Transferrin Antibody-Based Detection of Iron Deficiency Anemia*
**作者**: Smith A, et al.
**摘要**: 研究开发了一种基于转铁蛋白抗体的新型ELISA检测方法，用于高灵敏度测量血清中转铁蛋白水平，验证其在缺铁性贫血诊断中的临床应用价值。结果显示，该方法与铁代谢指标(如血清铁、铁蛋白)高度相关。
2. **文献名称**: *Anti-Transferrin Receptor Antibodies in Cancer Targeting*
**作者**: Lee J, et al.
**摘要**: 探讨转铁蛋白受体单克隆抗体在肿瘤靶向治疗中的作用，通过体外实验证明该抗体可特异性结合癌细胞表面过表达的转铁蛋白受体，并增强化疗药物递送效率，抑制肿瘤生长。
3. **文献名称**: *Autoantibodies to Transferrin in Neurodegenerative Disorders*
**作者**: Johnson R, et al.
**摘要**: 研究首次报道阿尔茨海默病患者脑脊液中存在抗转铁蛋白自身抗体，推测其可能干扰脑内铁稳态，导致神经元铁过载和氧化应激损伤，为神经退行性疾病机制提供新视角。
4. **文献名称**: *Transferrin Antibody Cross-Reactivity in Immunoassays*
**作者**: Gupta S, et al.
**摘要**: 分析商业转铁蛋白抗体在不同物种(人、小鼠、大鼠)间的交叉反应性，优化Western Blot和免疫组化实验条件，强调抗体特异性验证对实验可重复性的重要性。
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注：以上内容为模拟生成，实际文献需通过学术数据库(如PubMed、Web of Science)检索。
Transferrin antibodies are essential tools in biomedical research and diagnostics, targeting transferrin, a glycoprotein responsible for iron transport in the blood. Transferrin binds to iron ions (Fe³⁺) in the bloodstream, facilitating their delivery to cells via transferrin receptor-mediated endocytosis. This process is critical for maintaining iron homeostasis, as iron is vital for numerous physiological functions, including oxygen transport and enzyme activity.
Antibodies against transferrin are widely used to study its expression, localization, and function in various tissues. Polyclonal and monoclonal transferrin antibodies enable detection in techniques like ELISA, Western blotting, and immunohistochemistry. They are particularly valuable in diagnosing and monitoring conditions associated with abnormal iron metabolism, such as iron-deficiency anemia, hereditary hemochromatosis, and chronic liver diseases. Additionally, transferrin levels in cerebrospinal fluid (CSF) serve as biomarkers for blood-brain barrier integrity, aiding in the assessment of neurological disorders.
In cancer research, transferrin antibodies help investigate overexpression of transferrin receptors in malignant cells, a feature exploited in targeted drug delivery systems. Recent studies also explore their role in neurodegenerative diseases, where iron accumulation is linked to pathologies like Alzheimer’s and Parkinson’s. Overall, transferrin antibodies remain indispensable for unraveling iron-related mechanisms and advancing therapeutic strategies.
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