WB | 咨询技术 | Human,Mouse,Rat |
IF | 1/20-1/50 | Human,Mouse,Rat |
IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
ICC | 1/50-1/200 | Human,Mouse,Rat |
FCM | 1/20-1/100 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | C-C chemokine receptor type 2; C-C CKR-2; CC chemokine receptor type 2; CC CKR 2; CC-CKR-2; CCCKR2; CCR 2; CCR-2;; CCR1L;; CCR2;;CCR2 |
WB Predicted band size | 42 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | A synthesized peptide derived from human CCR2 |
Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于CCR2/CKR2抗体的3篇示例文献(注:文献为虚构示例,仅供格式参考):
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1. **文献名称**:*Selective Inhibition of CCR2 Signaling by a Novel Monoclonal Antibody Suppresses Neuroinflammation in Experimental Autoimmune Encephalomyelitis*
**作者**:Zhang Y, et al.
**摘要**:本研究开发了一种针对CCR2受体胞外域的单克隆抗体,可特异性阻断CCL2介导的信号通路。在实验性自身免疫性脑脊髓炎(EAE)模型中,该抗体显著抑制小胶质细胞活化和中枢神经系统炎症,提示其在多发性硬化症中的治疗潜力。
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2. **文献名称**:*Anti-CCR2 Antibody-Conjugated Nanoparticles for Targeted Delivery in Atherosclerotic Plaque Imaging*
**作者**:Wang L, et al.
**摘要**:作者将抗CCR2抗体与近红外荧光纳米颗粒结合,用于动脉粥样硬化斑块中单核/巨噬细胞的特异性标记。体内实验表明,该探针能精准定位斑块区域,为无创影像诊断提供了新策略。
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3. **文献名称**:*A Neutralizing CCR2 Antibody Reverses Chemotherapy Resistance by Reprogramming the Tumor Microenvironment*
**作者**:Garcia-Rojas M, et al.
**摘要**:研究发现,中和性CCR2抗体可通过阻断肿瘤相关巨噬细胞(TAMs)的招募,重塑免疫抑制性肿瘤微环境,增强化疗药物在胰腺癌模型中的疗效,并减少转移灶形成。
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**建议**:如需真实文献,可访问PubMed或Google Scholar,搜索关键词如“CCR2 antibody therapeutic”、“anti-CCR2 neutralization”或结合具体疾病(如癌症、动脉粥样硬化)。近年研究多聚焦于抗体药物偶联物(ADC)或联合免疫疗法。
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