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Rabbit Monoclonal CCR2/CKR2 Antibody

  • 中文名: CCR2/CKR2抗体
  • 别    名: C-C chemokine receptor type 2; C-C CKR-2; CC chemokine receptor type 2; CC CKR 2; CC-CKR-2; CCCKR2; CCR 2; CCR-2;; CCR1L;; CCR2;;CCR2
货号: IPDX17025
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesC-C chemokine receptor type 2; C-C CKR-2; CC chemokine receptor type 2; CC CKR 2; CC-CKR-2; CCCKR2; CCR 2; CCR-2;; CCR1L;; CCR2;;CCR2
WB Predicted band size42 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human CCR2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于CCR2/CKR2抗体的3篇示例文献(注:文献为虚构示例,仅供格式参考):

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1. **文献名称**:*Selective Inhibition of CCR2 Signaling by a Novel Monoclonal Antibody Suppresses Neuroinflammation in Experimental Autoimmune Encephalomyelitis*

**作者**:Zhang Y, et al.

**摘要**:本研究开发了一种针对CCR2受体胞外域的单克隆抗体,可特异性阻断CCL2介导的信号通路。在实验性自身免疫性脑脊髓炎(EAE)模型中,该抗体显著抑制小胶质细胞活化和中枢神经系统炎症,提示其在多发性硬化症中的治疗潜力。

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2. **文献名称**:*Anti-CCR2 Antibody-Conjugated Nanoparticles for Targeted Delivery in Atherosclerotic Plaque Imaging*

**作者**:Wang L, et al.

**摘要**:作者将抗CCR2抗体与近红外荧光纳米颗粒结合,用于动脉粥样硬化斑块中单核/巨噬细胞的特异性标记。体内实验表明,该探针能精准定位斑块区域,为无创影像诊断提供了新策略。

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3. **文献名称**:*A Neutralizing CCR2 Antibody Reverses Chemotherapy Resistance by Reprogramming the Tumor Microenvironment*

**作者**:Garcia-Rojas M, et al.

**摘要**:研究发现,中和性CCR2抗体可通过阻断肿瘤相关巨噬细胞(TAMs)的招募,重塑免疫抑制性肿瘤微环境,增强化疗药物在胰腺癌模型中的疗效,并减少转移灶形成。

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**建议**:如需真实文献,可访问PubMed或Google Scholar,搜索关键词如“CCR2 antibody therapeutic”、“anti-CCR2 neutralization”或结合具体疾病(如癌症、动脉粥样硬化)。近年研究多聚焦于抗体药物偶联物(ADC)或联合免疫疗法。

背景信息

The C-C chemokine receptor type 2 (CCR2 or CKR2) is a G protein-coupled receptor (GPCR) primarily expressed on immune cells, including monocytes, macrophages, and T lymphocytes. It binds to chemokines such as CCL2 (MCP-1), CCL7. and CCL8. playing a critical role in mediating leukocyte migration to sites of inflammation or injury. CCR2 signaling is implicated in various inflammatory and autoimmune diseases, as well as cancer metastasis, due to its involvement in immune cell recruitment and activation. Antibodies targeting CCR2 are developed to block this pathway, offering potential therapeutic benefits. These antibodies can inhibit receptor-ligand interactions, thereby reducing immune cell infiltration and inflammation. In research, CCR2 antibodies are used as tools to study receptor function, cellular trafficking, and disease mechanisms. Therapeutic applications are explored in conditions like rheumatoid arthritis, atherosclerosis, multiple sclerosis, and cancer, though challenges remain in achieving specificity and minimizing off-target effects. Some preclinical and clinical trials highlight their potential, but further optimization is needed to address redundancy in chemokine signaling and improve efficacy.

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