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Rabbit Monoclonal Flotillin2 Antibody

  • 中文名: Flotillin2抗体
  • 别    名: epidermal surface antigen; ESA; flotillin-2; Membrane component chromosome 17 surface marker 1; ESA1; M17S1;Flotillin 2
货号: IPDX17017
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliasesepidermal surface antigen; ESA; flotillin-2; Membrane component chromosome 17 surface marker 1; ESA1; M17S1;Flotillin 2
WB Predicted band size47 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Flotillin 2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇与Flotillin2抗体相关的文献示例(注:文献标题和作者为虚构示例,仅供参考格式):

1. **文献名称**:*Flotillin-2 modulates EGFR signaling and cancer cell invasion via lipid raft microdomains*

**作者**:Smith J. et al.

**摘要**:通过Flotillin2特异性抗体阻断实验,揭示其在调控表皮生长因子受体(EGFR)的脂筏定位及下游MAPK信号传导中的作用,促进乳腺癌细胞侵袭。

2. **文献名称**:*Flotillin-2 antibody reveals its essential role in neuronal endocytosis and synaptic vesicle recycling*

**作者**:Chen L. et al.

**摘要**:利用Flotillin2抗体进行免疫共沉淀和神经元成像,证明其与网格蛋白依赖性内吞途径相关,影响突触小泡循环和神经传递功能。

3. **文献名称**:*Flotillin-2 as a biomarker in exosome research: Antibody validation and functional implications*

**作者**:Garcia R. et al.

**摘要**:系统评估了Flotillin2抗体在细胞外囊泡(外泌体)标记中的特异性,确认其作为外泌体标志物的可靠性,并探讨其在肿瘤微环境中的潜在应用。

4. **文献名称**:*Targeting Flotillin-2 with monoclonal antibodies inhibits viral entry in influenza A infection*

**作者**:Kim H. et al.

**摘要**:开发了高特异性Flotillin2单克隆抗体,证明其通过破坏病毒与宿主细胞膜融合机制,显著抑制甲型流感病毒的感染效率。

(注:以上文献为示例性质,实际引用需查询真实数据库如PubMed。)

背景信息

Flotillin-2 antibodies are essential tools in studying the structure and function of membrane microdomains, particularly lipid rafts. Flotillin-2 (also known as reggie-1) is a conserved, ubiquitously expressed protein that localizes to cholesterol-rich membrane domains and plays roles in membrane trafficking, signal transduction, and cytoskeletal organization. It forms hetero-oligomers with its homolog Flotillin-1. contributing to cellular processes like endocytosis, cell adhesion, and pathogen entry. Antibodies targeting Flotillin-2 are widely used to investigate its expression, subcellular localization, and interactions in various contexts, including cancer metastasis, neuronal development, and immune responses. These antibodies (polyclonal or monoclonal) are validated for techniques such as Western blotting, immunofluorescence, and co-immunoprecipitation. Specificity is critical due to homology with Flotillin-1 and potential cross-reactivity. Researchers also utilize Flotillin-2 antibodies to explore its association with diseases; for example, elevated Flotillin-2 levels correlate with tumor progression and poor prognosis in certain cancers. Challenges include distinguishing membrane-bound versus cytosolic pools and accounting for post-translational modifications. Overall, Flotillin-2 antibodies remain pivotal in unraveling the biological and pathological significance of lipid raft-associated proteins.

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