| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CAV3; M-caveolin; Caveolin 3; VIP21;;Caveolin 3 |
| WB Predicted band size | 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Caveolin 3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Caveolin-3抗体的3篇参考文献(名称、作者及摘要概述)：
1. **文献名称**：*Caveolin-3 in Muscular Dystrophy and Cardiomyopathy*
**作者**：Scherer PE, et al.
**摘要**：该研究首次描述了Caveolin-3在骨骼肌和心肌细胞膜中的特异性表达，并发现其缺失或突变与肢带型肌营养不良和扩张型心肌病相关，为疾病机制提供了分子基础。
2. **文献名称**：*Role of Caveolin-3 in the Organization of Caveolae in Striated Muscle*
**作者**：Parton RG, et al.
**摘要**：通过免疫定位和抗体实验，揭示了Caveolin-3在肌肉细胞膜微结构(caveolae)形成中的关键作用，并证明其参与细胞膜机械传感和信号传递。
3. **文献名称**：*Caveolin-3 Gene Mutations and Protein Expression in Human Muscular Disorders*
**作者**：Woodman SE, et al.
**摘要**：分析Caveolin-3基因突变患者的肌肉活检样本，发现抗体检测显示蛋白表达显著减少或异常，提示其在肌纤维膜稳定性中的重要性及作为诊断标志物的潜力。
Caveolin-3 is a muscle-specific protein that serves as the primary structural component of caveolae, small invaginations in the plasma membrane involved in signal transduction, lipid regulation, and membrane trafficking. It is encoded by the CAV3 gene and is predominantly expressed in cardiac and skeletal muscle tissues. Caveolin-3 plays critical roles in maintaining membrane integrity, stabilizing ion channels, and modulating signaling pathways such as nitric oxide synthesis and calcium handling. Dysregulation or mutations in CAV3 are linked to various muscular disorders, including limb-girdle muscular dystrophy type 1C, rippling muscle disease, hypertrophic cardiomyopathy, and idiopathic hyperCKemia.
Caveolin-3 antibodies are essential tools for detecting and quantifying this protein in research and diagnostics. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its expression, localization, and interactions in cellular or tissue samples. These antibodies help identify pathogenic mutations, assess protein dysregulation in muscle biopsies, and investigate disease mechanisms in preclinical models. Commercially available antibodies target specific epitopes, often validated for species cross-reactivity (e.g., human, mouse, rat). Quality validation via knockout controls ensures specificity, minimizing false-positive results. In clinical settings, Caveolin-3 antibodies aid in diagnosing inherited myopathies and guiding personalized therapeutic strategies. Their utility underscores the protein’s significance in both basic muscle biology and translational medicine.
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