| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human FETUB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于FETUB抗体的研究文献示例(注：以下为虚拟示例，实际文献需通过学术数据库验证)：
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1. **文献名称**：《FETUB作为卵巢储备功能评估的新型血清标志物》
**作者**：Smith A, et al. (2021)
**摘要**：研究通过ELISA技术检测血清中FETUB蛋白水平，发现其与抗苗勒管激素(AMH)呈正相关，提示FETUB抗体可作为卵巢储备功能下降的潜在生物标志物。
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2. **文献名称**：《FETUB在非酒精性脂肪肝中的表达及机制研究》
**作者**：Chen L, et al. (2020)
**摘要**：利用FETUB特异性抗体进行Western blot和免疫组化分析，发现肝脏FETUB表达与脂肪变性程度相关，提示其在脂代谢调控中的作用。
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3. **文献名称**：《FETUB抗体在男性不育症精液分析中的应用》
**作者**：Kumar R, et al. (2019)
**摘要**：通过免疫荧光技术检测精液中FETUB蛋白分布，发现低表达与精子活力下降显著相关，为男性不育诊断提供新靶点。
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4. **文献名称**：《多囊卵巢综合征患者卵泡液中FETUB水平与胰岛素抵抗的关联》
**作者**：Zhang Y, et al. (2022)
**摘要**：采用FETUB单克隆抗体检测卵泡液样本，发现FETUB水平升高与胰岛素抵抗指数(HOMA-IR)正相关，暗示其在PCOS代谢异常中的病理角色。
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**建议**：实际文献可通过PubMed、Google Scholar等平台以关键词“FETUB antibody”、“Fetuin-B biomarker”检索，并筛选近五年高被引研究。
**Background of FETUB Antibodies**
FETUB (Fetuin-B) is a liver-secreted protein belonging to the cystatin superfamily, initially recognized for its role in reproductive biology. It is structurally similar to fetuin-A (alpha-2-HS-glycoprotein) but exhibits distinct functional properties. FETUB is critical in regulating sperm motility and zona pellucida hardening during fertilization, acting as a protease inhibitor to prevent premature egg activation. Studies highlight its involvement in metabolic processes, including insulin signaling and lipid metabolism, with potential links to obesity and diabetes.
Antibodies targeting FETUB are essential tools for investigating its expression, localization, and mechanistic roles. They enable detection via techniques like ELISA, Western blotting, and immunohistochemistry, aiding research in reproductive health, metabolic disorders, and liver function. FETUB antibodies also hold diagnostic potential, as altered FETUB levels correlate with conditions such as polycystic ovary syndrome (PCOS) and non-alcoholic fatty liver disease (NAFLD). Recent research explores therapeutic applications, including modulating FETUB activity to address infertility or metabolic dysregulation. Challenges remain in standardizing antibody specificity and understanding isoform-specific functions. Overall, FETUB antibodies are pivotal in unraveling the protein’s diverse physiological and pathological contributions, bridging gaps between basic science and clinical translation.
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