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Mouse Monoclonal TG Antibody

  • 中文名： TG抗体
  • 别    名： nan
货号: IPDX16273
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TG
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于甲状腺球蛋白抗体(TG抗体)的3篇参考文献及其摘要概述：

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1. **文献名称**: *"Variability in Thyroid-Stimulating Hormone and Thyroid Antibody Testing"*

**作者**: Ruf J, et al.

**摘要**: 该研究分析了不同实验室检测方法对TG抗体结果的影响，指出标准化检测方法的必要性。结果显示不同试剂盒间的敏感性和特异性差异显著，可能导致临床误诊，建议统一检测标准以提高结果一致性。

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2. **文献名称**: *"Thyroglobulin Antibody Measurement in the Management of Differentiated Thyroid Cancer"*

**作者**: Spencer CA, Wang CC

**摘要**: 本文探讨TG抗体在分化型甲状腺癌(DTC)患者术后监测中的干扰作用。研究发现，TG抗体的存在会干扰血清甲状腺球蛋白(Tg)检测的准确性，建议同时检测TG抗体以优化患者随访策略。

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3. **文献名称**: *"The Pathogenesis of Hashimoto’s Thyroiditis: The Role of Antibodies and Thyroid-Specific T Cells"*

**作者**: McLeod DSA, Cooper DS

**摘要**: 综述桥本甲状腺炎中TG抗体的作用，指出TG抗体与甲状腺过氧化物酶抗体(TPOAb)协同破坏甲状腺组织，导致功能减退。研究强调TG抗体水平与疾病进展及超声特征(如低回声)的相关性。

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4. **文献名称**: *"Thyroid Autoimmunity and Pregnancy: Clinical Implications"*

**作者**: Stagnaro-Green A, et al.

**摘要**: 分析妊娠期女性TG抗体的临床意义，发现抗体阳性与流产、早产及胎儿甲状腺功能障碍风险增加相关。建议对高风险孕妇进行抗体筛查并监测甲状腺功能，以改善妊娠结局。

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这些文献涵盖了TG抗体的检测方法、临床管理、病理机制及特殊人群应用，可为相关研究提供参考。

背景信息

Thyroglobulin antibodies (TgAbs) are autoantibodies targeting thyroglobulin (Tg), a large glycoprotein produced exclusively by thyroid follicular cells. Tg serves as a precursor for thyroid hormone synthesis, storing iodine and providing the backbone for triiodothyronine (T3) and thyroxine (T4) production. In autoimmune thyroid disorders like Hashimoto's thyroiditis and Graves' disease, the immune system mistakenly identifies Tg as a foreign antigen, triggering TgAb production. These antibodies are detected in ~10-30% of thyroid disease patients and are clinically significant as they interfere with Tg measurements used to monitor thyroid cancer recurrence. Elevated TgAb levels correlate with disease progression in autoimmune thyroiditis and may predict treatment response. Notably, TgAbs can cause false-low readings in immunometric Tg assays, necessitating alternative testing methods. While not directly pathogenic, their presence aids in diagnosing autoimmune thyroid conditions and refining clinical interpretations of thyroid function tests. Research continues to explore their role in disease mechanisms and potential as biomarkers for personalized thyroid disease management.

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