| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human GMPR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于GMPR2抗体的模拟参考文献示例(仅供格式参考，非真实文献)：
1. **《GMPR2在结直肠癌中的表达调控及临床意义》**
作者：Smith J, et al.
摘要：本研究通过免疫组化分析发现GMPR2蛋白在结直肠癌组织中显著下调，其表达水平与患者预后呈正相关。研究使用特异性GMPR2抗体证实了其在肿瘤代谢重编程中的作用。
2. **《GMPR2缺失加剧神经退行性疾病中的氧化应激损伤》**
作者：Johnson L, et al.
摘要：文章利用GMPR2抗体检测小鼠脑组织中的蛋白分布，发现GMPR2在阿尔茨海默病模型中表达降低，并通过调控NADPH代谢影响神经元抗氧化能力。
3. **《肥胖相关代谢紊乱中GMPR2的功能研究》**
作者：Zhang Y, et al.
摘要：通过Western blot和免疫荧光技术(使用GMPR2抗体)，研究发现肥胖小鼠脂肪组织中GMPR2表达异常，提示其可能通过嘌呤代谢途径影响炎症反应。
4. **《GMPR2与p53相互作用在细胞周期调控中的新机制》**
作者：Lee S, et al.
摘要：该研究利用GMPR2抗体进行免疫共沉淀实验，揭示了GMPR2与p53蛋白的直接结合，并证实其在DNA损伤修复中的协同作用。
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**注意**：以上为模拟示例，实际文献需通过PubMed、Web of Science等数据库检索。建议使用关键词“GMPR2 antibody”“GMP reductase 2”或结合研究领域(如“癌症”“代谢疾病”)进行精准查询。
The GMPR2 (Guanosine Monophosphate Reductase 2) antibody is a tool used to detect and study the GMPR2 protein, an enzyme involved in purine metabolism. GMPR2 catalyzes the NADPH-dependent reduction of GMP to IMP, playing a role in maintaining nucleotide pool balance. Unlike its paralog GMPR1. which is broadly expressed, GMPR2 exhibits tissue-specific expression, with higher levels in the liver, kidney, and testes. Research on GMPR2 is limited but growing, as dysregulation of purine metabolism is linked to metabolic disorders, immune dysfunction, and cancer.
The antibody is typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. It enables applications such as Western blotting, immunohistochemistry, and immunofluorescence to analyze GMPR2 expression, localization, and regulation. Studies suggest GMPR2 may act as a tumor suppressor in certain cancers, with reduced expression correlating with poor prognosis. Its interaction with metabolic pathways also highlights potential roles in drug resistance and cellular stress responses. Validation of GMPR2 antibodies includes specificity checks via knockout controls and cross-reactivity assessments. This tool aids in elucidating GMPR2's biological significance and therapeutic potential.
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