| WB | 咨询技术 | Mouse, Rat |
| IF | 咨询技术 | Mouse, Rat |
| IHC | 咨询技术 | Mouse, Rat |
| ICC | 技术咨询 | Mouse, Rat |
| FCM | 咨询技术 | Mouse, Rat |
| Elisa | 咨询技术 | Mouse, Rat |
| Aliases | SPN; LSN; GALGP; GPL115 |
| Entrez GeneID | 6693 |
| clone | 1H8B10 |
| WB Predicted band size | 40.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD43 (AA: extra 20-253) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于Rab6b抗体的3篇参考文献的简要信息：
1. **文献名称**: "Rab6b regulates cell migration and invasion by modulating focal adhesion dynamics"
**作者**: Chen X, et al.
**摘要**: 该研究使用Rab6b特异性抗体，通过免疫印迹和免疫荧光技术，发现Rab6b通过调控黏着斑的稳定性影响肿瘤细胞的迁移和侵袭能力，揭示其在癌症转移中的潜在作用。
2. **文献名称**: "Subcellular localization and functional characterization of Rab6b in neuronal cells"
**作者**: Smith J, et al.
**摘要**: 作者利用Rab6b抗体进行亚细胞定位分析，发现Rab6b主要分布于高尔基体和运输囊泡中，并参与神经细胞中神经营养因子的分泌过程，提示其在神经元功能中的重要性。
3. **文献名称**: "Rab6b interacts with Bicaudal-D1 to regulate dynein-mediated retrograde transport"
**作者**: Lee S, et al.
**摘要**: 研究通过免疫共沉淀(使用Rab6b抗体)和活细胞成像，证明Rab6b与Bicaudal-D1蛋白互作，协同调控动力蛋白介导的逆向运输，影响细胞内膜系统动态平衡。
注：上述文献为示例，实际引用时需根据具体研究内容核实原文信息。如需真实文献，建议通过PubMed或Google Scholar以“Rab6b antibody”或“Rab6b function”为关键词检索。
The Rab6b antibody is a valuable tool in cellular and molecular biology research, specifically targeting the Rab6b protein, a member of the Rab GTPase family. Rab proteins are critical regulators of membrane trafficking, organelle dynamics, and intracellular transport. Rab6b, one of two isoforms encoded by the RAB6 gene (alongside Rab6a), localizes predominantly to the Golgi apparatus and regulates retrograde vesicular transport between the Golgi and endoplasmic reticulum (ER). It also influences secretory pathways, cell migration, and cytokinesis. Unlike Rab6a, Rab6b contains distinct C-terminal sequences, which may confer unique interaction partners or functional specializations.
Rab6b antibodies are commonly used to study the protein's expression, subcellular localization, and interactions in various biological contexts. These antibodies enable techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding investigations into Rab6b's role in diseases. For instance, altered Rab6b expression has been linked to neurodegenerative disorders (e.g., Alzheimer's disease) and cancers, where dysregulated vesicular trafficking contributes to pathogenesis. Researchers also utilize Rab6b antibodies to explore its interplay with effector proteins, such as molecular motors (e.g., dynein) or tethering factors, to elucidate mechanisms of organelle positioning and cargo sorting. Commercial Rab6b antibodies are typically raised in rabbits or mice, with validation including knockout cell lines or siRNA knockdown to confirm specificity.
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