| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human IFNA2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于IFNA2抗体的3篇参考文献示例(注：以下内容为假设性模拟，实际文献需通过学术数据库检索确认)：
1. **"Monoclonal Antibody-Based Detection of Interferon Alpha 2 (IFNA2) in Human Serum"**
- **作者**: Smith J., et al.
- **摘要**: 研究开发了一种高特异性的单克隆抗体，用于定量检测人血清中的IFNA2蛋白，验证了其在慢性病毒感染患者中的诊断价值。
2. **"IFNA2 Autoantibodies as Biomarkers in Autoimmune Diseases"**
- **作者**: Lee S., Zhang Y.
- **摘要**: 探讨了IFNA2自身抗体在系统性红斑狼疮(SLE)患者中的出现频率及其与疾病活动度的相关性，提示其可能作为自身免疫疾病的潜在生物标志物。
3. **"Targeting IFNA2 in Tumor Microenvironments: Therapeutic Implications of Neutralizing Antibodies"**
- **作者**: Chen L., et al.
- **摘要**: 通过体外实验证明，阻断IFNA2的中和抗体能够抑制肿瘤微环境中的促炎信号通路，为癌症免疫治疗提供了新策略。
如需具体文献，建议在PubMed或Web of Science中检索关键词“IFNA2 antibody”“interferon alpha 2 antibody”。
IFNA2 antibodies are immunological tools targeting interferon-alpha 2 (IFNA2), a cytokine belonging to the type I interferon family. IFNA2 plays a critical role in innate immunity by activating antiviral defenses, modulating immune cell activity, and inhibiting tumor cell proliferation. It signals through the JAK-STAT pathway, inducing the expression of interferon-stimulated genes (ISGs) that mediate its biological effects. Antibodies against IFNA2 are widely used in research to study its expression, signaling mechanisms, and involvement in diseases such as autoimmune disorders (e.g., lupus), viral infections, and cancers.
Monoclonal IFNA2 antibodies offer high specificity for quantitative assays like ELISA or Western blotting, while polyclonal versions may detect broader epitopes in immunohistochemistry. Some therapeutic antibodies targeting IFNA2 are under investigation to neutralize its activity in autoimmune conditions where excessive interferon signaling drives pathology. Conversely, detecting IFNA2 levels in clinical samples can aid in diagnosing interferonopathies or monitoring antiviral responses.
Commercial IFNA2 antibodies are typically validated for cross-reactivity across species (e.g., human, mouse) and tested for sensitivity in complex biological matrices. Their applications extend to elucidating interferon dynamics in immunotherapy and viral pathogenesis, making them essential for both basic research and translational studies.
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