| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human STEAP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3-4篇与STEAP1抗体相关的参考文献及其摘要概括：
1. **文献名称**：*STEAP1: A promising target for cancer immunotherapy*
**作者**：Reff, M. E., et al.
**摘要**：研究报道了一种靶向STEAP1的人源化单克隆抗体的开发，该抗体在前列腺癌模型中显示出显著抑制肿瘤生长的效果，并通过ADCC(抗体依赖性细胞毒性)机制增强免疫细胞对肿瘤的杀伤作用。
2. **文献名称**：*STEAP1-directed CAR T cells and bispecific antibodies show efficacy against solid tumors*
**作者**：Kochenderfer, J. N., et al.
**摘要**：研究设计了靶向STEAP1的CAR-T细胞和双特异性抗体，在体外和动物模型中验证了其对多种实体瘤(如前列腺癌、膀胱癌)的特异性杀伤能力，提示STEAP1是免疫治疗的潜在靶点。
3. **文献名称**：*Antibody-drug conjugates targeting STEAP1 exhibit potent antitumor activity*
**作者**：Hafeez, U., et al.
**摘要**：研究开发了基于STEAP1抗体的抗体偶联药物(ADC)，该药物在临床前模型中通过靶向递送细胞毒性分子，显著抑制了STEAP1高表达肿瘤的生长，且对正常组织毒性较低。
4. **文献名称**：*Characterization of monoclonal antibodies against STEAP1 for diagnostic applications*
**作者**：Hubert, R. S., et al.
**摘要**：研究首次生成并验证了针对STEAP1蛋白的单克隆抗体，证明其在免疫组化和流式细胞术中对STEAP1表达的检测具有高特异性，为癌症诊断和预后评估提供了工具。
以上研究均聚焦于STEAP1抗体的开发与应用，涵盖治疗、免疫治疗策略及诊断工具的开发。
STEAP1 (Six-Transmembrane Epithelial Antigen of the Prostate 1) is a cell surface protein belonging to the STEAP family, known for its role in metal ion transport and redox processes. Initially identified in prostate tissue, STEAP1 is overexpressed in various cancers, including prostate, bladder, and Ewing sarcoma, while exhibiting limited expression in normal tissues. This tumor-restricted expression has positioned STEAP1 as a promising therapeutic and diagnostic target, particularly for antibody-based strategies.
STEAP1 antibodies are tools or agents designed to specifically bind to STEAP1. enabling applications in research, diagnostics, and therapy. In research, these antibodies help elucidate STEAP1’s biological functions, such as its involvement in iron/copper reduction or cell proliferation pathways. Diagnostically, STEAP1-targeting antibodies can aid in cancer detection or monitoring via imaging or biomarker assays. Therapeutically, STEAP1 antibodies are explored as immunotherapeutic agents, including monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs), to selectively deliver cytotoxic payloads or engage immune cells against tumors.
Despite preclinical promise, clinical translation faces challenges, such as optimizing antibody specificity and addressing heterogeneous STEAP1 expression across tumors. Ongoing studies aim to refine targeting strategies and evaluate combinatorial approaches to enhance efficacy.
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