Mouse Monoclonal RNF113B Antibody

The RNF113B antibody is a research tool designed to detect and study the RNF113B protein, a member of the RING finger (Really Interesting New Gene) family of E3 ubiquitin ligases. RNF113B contains a conserved RING domain that facilitates interactions with E2 ubiquitin-conjugating enzymes, enabling the transfer of ubiquitin to target substrates. This post-translational modification regulates diverse cellular processes, including protein degradation, DNA repair, and signal transduction. While the full functional scope of RNF113B remains under investigation, studies suggest its involvement in RNA processing, cell cycle regulation, and response to DNA damage. Dysregulation of RNF113B has been implicated in certain cancers and genetic disorders, such as X-linked intellectual disability, where mutations in the RNF113B gene are linked to impaired neurological development. The antibody is commonly used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to analyze protein expression, localization, and interaction partners. Researchers rely on validated RNF113B antibodies to explore its biological roles, with specificity confirmed through knockout controls or siRNA knockdown experiments. Ongoing studies aim to clarify its molecular mechanisms and therapeutic potential in disease contexts.