| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TRIM43B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于TRIM43B抗体的3篇参考文献(基于真实研究领域推测，具体文献需通过数据库核实)：
1. **文献名称**：*"TRIM43B is a novel placental antigen identified by antibody-based proteomic analysis"*
**作者**：Smith A, et al.
**摘要**：通过蛋白质组学筛选胎盘特异性抗原，发现TRIM43B在胎盘滋养层细胞高表达，并开发了特异性抗体用于妊娠相关疾病研究。
2. **文献名称**：*"Epigenetic regulation and antibody targeting of TRIM43B in colorectal cancer"*
**作者**：Li X, et al.
**摘要**：研究TRIM43B在结直肠癌中的表观遗传失调，利用定制抗体证实其过表达与患者预后不良相关，提示其作为治疗靶点的潜力。
3. **文献名称**：*"Characterization of TRIM43B antibody for detecting oncogenic variants in glioblastoma"*
**作者**：Wang Y, et al.
**摘要**：报道了一种高特异性TRIM43B单克隆抗体的开发，通过免疫组化验证其在胶质母细胞瘤中的异常表达，并关联其与肿瘤侵袭性。
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**注意**：以上文献为示例格式，实际研究中TRIM43B相关抗体文献较少，建议通过PubMed或Google Scholar以“TRIM43B antibody”或“TRIM43B expression”为关键词检索最新文献。部分研究可能聚焦于TRIM家族(如TRIM43或TRIM28)，需结合具体实验需求筛选。
The TRIM43B antibody is designed to target the TRIM43B protein, a member of the tripartite motif (TRIM) family characterized by conserved RING, B-box, and coiled-coil domains. TRIM proteins are involved in diverse cellular processes, including antiviral defense, transcriptional regulation, and apoptosis. TRIM43B, specifically, is part of a primate-specific gene cluster on chromosome 15. with paralogs TRIM43 and TRIM48. Its expression is predominantly observed in germ cells, placental tissues, and certain cancers, suggesting roles in reproduction, development, or oncogenesis. However, its precise biological functions remain poorly understood due to limited studies.
The TRIM43B antibody is utilized in research to investigate protein localization, expression patterns, and molecular interactions. It aids in detecting TRIM43B via techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF), contributing to studies on its potential involvement in tumorigenesis or germ cell maturation. Some evidence links TRIM43B overexpression to genomic instability in cancers, hinting at oncogenic properties. Additionally, its restricted expression in normal tissues makes it a candidate biomarker for germ cell tumors or certain malignancies. Researchers also explore its role in epigenetic regulation, as TRIM proteins often modulate ubiquitination pathways. Despite its emerging relevance, functional studies are ongoing, and the antibody serves as a critical tool to unravel TRIM43B's contributions to cellular physiology and disease.
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