| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HSPA2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于HSPA2抗体的3篇参考文献(信息基于公开研究整理，部分为示例性概括)：
1. **文献名称**：*HSPA2 Antibody Characterization in Human Spermatozoa: Implications for Male Fertility*
**作者**：Smith et al.
**摘要**：研究验证了一种特异性HSPA2抗体的应用，发现其在检测人类精子中HSPA2表达水平的可靠性，并揭示HSPA2低表达与男性不育症的相关性。
2. **文献名称**：*Targeting HSPA2 in Cancer: Development of a Monoclonal Antibody for Therapeutic Potential*
**作者**：Li & Zhang
**摘要**：报道了一种新型抗HSPA2单克隆抗体的开发，该抗体能特异性结合肿瘤细胞表面的HSPA2蛋白，在体外实验中抑制癌细胞增殖并增强化疗敏感性。
3. **文献名称**：*HSPA2 Expression in Glioblastoma: Validation of a Polyclonal Antibody for Immunohistochemical Analysis*
**作者**：Wang et al.
**摘要**：评估了一种多克隆HSPA2抗体在胶质母细胞瘤组织中的适用性，证实其可用于IHC检测，并发现HSPA2高表达与患者预后不良相关。
注：实际文献需通过学术数据库(如PubMed、Web of Science)检索确认，以上内容为基于HSPA2常见研究方向的模拟概括。
HSPA2 (Heat Shock Protein Family A Member 2), a member of the 70 kDa heat shock protein (HSP70) family, plays critical roles in protein folding, stress response, and cellular homeostasis. It is highly conserved and shares structural homology with other HSP70 proteins, featuring an N-terminal ATPase domain and a C-terminal substrate-binding domain. HSPA2 is particularly notable for its tissue-specific expression, with high levels observed in the testes, where it supports spermatogenesis by stabilizing key proteins during meiotic divisions. It also participates in stress adaptation, apoptosis regulation, and cancer progression, often upregulated in malignancies like breast and lung cancer, correlating with poor prognosis.
HSPA2 antibodies are essential tools for studying its expression, localization, and function. These antibodies are developed using immunogens derived from specific regions of the HSPA2 protein, such as peptide sequences near the N- or C-terminus. Validated across applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), they help detect HSPA2 in human, mouse, or rat samples. Some commercially available clones (e.g., 2B4/2H9. EPR3507) demonstrate high specificity, often confirmed by knockout/knockdown validation. Researchers use HSPA2 antibodies to explore its role in cancer biology, reproductive health, and neurodegenerative diseases, where protein misfolding stress is implicated. Cross-reactivity with other HSP70 isoforms remains a consideration, requiring careful experimental controls.
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