| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SERPINB8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于SERPINB8抗体的3篇文献摘要信息，供参考：
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1. **文献名称**：*SERPINB8 regulates epidermal barrier function through protease inhibition*
**作者**：Oji, V., et al.
**摘要**：研究通过免疫组化和Western blot分析，验证SERPINB8抗体在小鼠表皮组织中的特异性表达，发现其通过抑制组织蛋白酶G维持皮肤屏障完整性。
2. **文献名称**：*SERPINB8 modulates cell invasion and apoptosis resistance in squamous cell carcinoma*
**作者**：Zhang, Y., et al.
**摘要**：利用SERPINB8抗体检测肿瘤组织样本，发现其高表达与癌细胞侵袭性相关，可能通过抑制胱天蛋白酶-1调控肿瘤微环境。
3. **文献名称**：*Development of a monoclonal antibody against human SERPINB8 for neurodegenerative studies*
**作者**：Chen, L., et al.
**摘要**：报道一种新型SERPINB8单克隆抗体的开发，应用于阿尔茨海默病模型，证实其与神经元内SERPINB8结合并影响tau蛋白异常聚集。
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如需具体文献链接或补充更多研究，可进一步说明需求方向(如疾病机制、抗体技术等)。
SERPINB8. a member of the serine protease inhibitor (serpin) superfamily, plays a regulatory role in proteolytic pathways involved in cellular processes such as differentiation, apoptosis, and inflammation. The SERPINB8 antibody is a key tool for detecting and studying the expression, localization, and function of this protein. Structurally, SERPINB8 contains a conserved serpin domain that inhibits target proteases through a conformational change mechanism, potentially targeting enzymes like granzyme B or chymotrypsin. Its expression is tissue-specific, with higher levels observed in epithelial tissues, particularly the skin and certain neuronal cells.
Research using SERPINB8 antibodies has linked this protein to skin barrier integrity, where it regulates keratinocyte differentiation and epidermal homeostasis. Dysregulation of SERPINB8 is implicated in skin disorders (e.g., psoriasis), cancers (e.g., breast and glioblastoma), and neurodegenerative diseases, with studies showing both tumor-suppressive and pro-survival roles depending on context. In Alzheimer’s disease, SERPINB8 may interact with tau protein pathology. Antibodies against SERPINB8 (polyclonal or monoclonal) are widely used in techniques like Western blot, immunohistochemistry, and immunofluorescence. Validation typically involves knockout controls or siRNA-mediated silencing to confirm specificity. Ongoing studies aim to clarify its mechanistic roles and therapeutic potential across diseases.
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