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Mouse Monoclonal DPCD Antibody

  • 中文名： DPCD抗体
  • 别    名： nan
货号: IPDX15886
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/250 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human DPCD
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于DPCD抗体的3篇示例参考文献(注：部分内容为示例性描述，建议通过学术数据库核实真实文献)：

1. **文献名称**：*DPCD is a ciliary protein required for primary cilium assembly and cell cycle regulation*

**作者**：Smith A, et al.

**摘要**：本研究证实DPCD蛋白在纤毛发生中的关键作用，并利用DPCD抗体进行免疫荧光实验，发现其缺失导致细胞周期停滞，揭示了其在纤毛相关疾病中的潜在机制。

2. **文献名称**：*Generation and characterization of a monoclonal antibody against human DPCD for respiratory disease studies*

**作者**：Li X, Wang Y.

**摘要**：报道了一种新型DPCD单克隆抗体的开发，验证了其在Western blot和免疫组化中的特异性，应用于慢性鼻窦炎患者组织样本分析，发现DPCD表达与纤毛功能障碍显著相关。

3. **文献名称**：*DPCD interacts with CEP290 and modulates ciliogenesis in zebrafish models*

**作者**：Garcia R, et al.

**摘要**：通过DPCD抗体进行共免疫沉淀实验，发现其与CEP290蛋白相互作用，利用斑马鱼模型证明DPCD缺失导致纤毛结构异常，为纤毛疾病机制提供了新见解。

(提示：以上为示例文献，实际研究中建议通过PubMed或Google Scholar检索最新文献，并关注抗体应用场景如疾病机制、诊断标志物等方向。)

背景信息

DPCD (Deleted in Primary Ciliary Dyskinesia) antibodies target proteins associated with ciliary function, particularly in the context of primary ciliary dyskinesia (PCD), a rare genetic disorder characterized by impaired motile cilia movement. Cilia are hair-like structures critical for mucociliary clearance, respiratory health, and embryonic development. DPCD, initially identified as a gene deleted in some PCD patients, encodes a protein involved in ciliogenesis or ciliary motility, though its precise molecular role remains under investigation. Mutations in DPCD are linked to ciliary ultrastructural defects, leading to chronic respiratory infections, sinusitis, and situs inversus (abnormal organ positioning). DPCD antibodies are primarily used in research to study protein expression, localization, and interaction networks within cilia, aiding in understanding PCD pathogenesis. They also serve as diagnostic tools in immunohistochemistry or immunofluorescence to detect DPCD protein deficiencies in patient-derived samples. Beyond PCD, these antibodies contribute to broader ciliopathy research, as ciliary dysfunction underlies diverse conditions like polycystic kidney disease and retinal degeneration. Developing DPCD antibodies faces challenges due to the protein’s low abundance and structural complexity. However, advances in epitope mapping and monoclonal antibody production continue to enhance their specificity, supporting both mechanistic studies and potential therapeutic strategies targeting ciliary pathways.

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