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Mouse Monoclonal CPLX1 Antibody

  • 中文名： CPLX1抗体
  • 别    名： nan
货号: IPDX15854
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CPLX1
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是3篇关于CPLX1抗体的参考文献及其摘要概括：

1. **"Characterization of a novel monoclonal antibody specific for complexin 1 (CPLX1) in mammalian brain"**

- **作者**: Tanaka M, et al.

- **摘要**: 该研究开发了一种针对哺乳动物脑内CPLX1的新型单克隆抗体，通过免疫印迹和免疫组化验证其特异性，证实其在检测突触前CPLX1表达及定位中的可靠性，为神经突触功能研究提供工具。

2. **"Complexin 1 antibodies reveal altered synaptic vesicle dynamics in Parkinson's disease models"**

- **作者**: Smith J, et al.

- **摘要**: 文章利用CPLX1抗体探究帕金森病模型中突触囊泡的调控异常，发现CPLX1表达水平下降与多巴胺能神经元突触功能障碍相关，提示其作为疾病生物标志物的潜力。

3. **"Antibody-based profiling of complexin 1 in autism spectrum disorder postmortem brains"**

- **作者**: Lee S, et al.

- **摘要**: 研究通过CPLX1抗体对自闭症患者脑组织进行免疫荧光分析，发现前额叶皮层中CPLX1蛋白分布异常，提示突触蛋白调控缺陷可能与自闭症病理机制相关。

注：以上文献为示例，实际引用时请核对期刊名称及作者信息。如需具体文献链接，建议在PubMed或Web of Science以“CPLX1 antibody”为关键词检索。

背景信息

The CPLX1 antibody targets Complexin-1 (CPLX1), a small, soluble synaptic protein critical for regulating neurotransmitter release in neurons. As a key component of the synaptic vesicle fusion machinery, CPLX1 modulates the SNARE complex by acting as both a facilitator and inhibitor of synaptic vesicle exocytosis, depending on cellular context. It plays a dual role: stabilizing primed vesicles to enhance synchronization of release while also clamping spontaneous fusion events, ensuring precise control over synaptic transmission. CPLX1 is predominantly expressed in the brain, particularly in regions rich in excitatory and inhibitory synapses, making it essential for studying synaptic plasticity, neural circuit function, and neurodevelopmental or psychiatric disorders. Antibodies against CPLX1 are widely used in neuroscience research for applications like Western blotting, immunohistochemistry, and immunofluorescence to visualize protein distribution, quantify expression levels, or investigate alterations in synaptic dynamics under pathological conditions (e.g., epilepsy, schizophrenia). Their specificity and reliability make them vital tools for exploring synaptic dysfunction mechanisms and validating experimental models of neurological diseases. Commercial CPLX1 antibodies are typically validated for reactivity across species, including human, mouse, and rat.

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