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Mouse Monoclonal NPTXR Antibody

  • 中文名： NPTXR抗体
  • 别    名： nan
货号: IPDX15856
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human NPTXR
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于NPTXR抗体的参考文献示例(内容基于模拟生成，非真实文献)：

1. **文献名称**：*NPTXR regulates synaptic plasticity and memory formation through glutamate receptor clustering*

**作者**：Yamada T, et al.

**摘要**：本研究利用特异性NPTXR抗体在小鼠海马组织中进行免疫组化分析，发现NPTXR通过调控AMPA受体的聚集影响突触可塑性和长期记忆形成。抗体验证显示其在神经元突触前膜的高表达。

2. **文献名称**：*Altered expression of NPTXR in autism spectrum disorder: Insights from post-mortem brain analysis*

**作者**：Smith J, et al.

**摘要**：通过Western blot和免疫荧光技术(使用NPTXR多克隆抗体)，研究发现自闭症患者前额叶皮层中NPTXR蛋白水平显著降低，提示其与突触连接异常及行为表型相关。

3. **文献名称**：*NPTXR antibody-based profiling reveals its role in neurodegenerative disease pathology*

**作者**：Chen L, et al.

**摘要**：该研究开发了一种高特异性NPTXR单克隆抗体，用于阿尔茨海默病模型小鼠的脑切片分析，发现NPTXR表达减少与β-淀粉样蛋白沉积区域突触丢失密切相关。

4. **文献名称**：*NPTXR modulates inhibitory synapse assembly in developing cortical neurons*

**作者**：Kim S, et al.

**摘要**：通过免疫共沉淀和共聚焦显微术(依赖NPTXR抗体)，研究证实NPTXR在发育中的皮层神经元内与GABA能突触蛋白相互作用，影响抑制性神经回路形成。

(注：以上文献为示例性内容，实际引用请查询真实数据库。)

背景信息

The neuronal pentraxin receptor (NPTXR) is a synaptic protein belonging to the neuronal pentraxin family, which includes secreted glycoproteins involved in synaptic plasticity and neural development. NPTXR is primarily localized at excitatory synapses and interacts with other pentraxins like NP1 and NPR to mediate the clustering of AMPA-type glutamate receptors, facilitating synaptic transmission and remodeling. Structurally, it contains an N-terminal pentraxin domain and a C-terminal transmembrane region, distinguishing it from secreted family members. Antibodies targeting NPTXR are critical tools for studying its expression, localization, and functional roles in both physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate synaptic organization in brain tissues or neuronal cultures. Research has linked NPTXR dysregulation to neurodevelopmental disorders (e.g., autism spectrum disorders), neurodegenerative diseases (e.g., Alzheimer’s), and psychiatric conditions, where synaptic dysfunction is a hallmark. These antibodies also aid in exploring NPTXR's potential as a biomarker or therapeutic target, particularly in conditions involving impaired synaptic connectivity or neuroinflammation.

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