Mouse Monoclonal HERC4 Antibody

The HERC4 antibody is a tool used to study the HERC4 protein, a member of the HERC (HECT and RCC1-like domain-containing) family of ubiquitin ligases. HERC4. encoded by the *HERC4* gene in humans, plays roles in ubiquitination, a post-translational modification critical for protein degradation, trafficking, and signaling. It contains a HECT domain (responsible for ubiquitin ligase activity) and RCC1-like repeats (implicated in guanine nucleotide exchange). While less characterized than other HERC proteins (e.g., HERC1 or HERC2), HERC4 has been linked to cellular processes such as spermatogenesis, antiviral responses, and cancer progression. Studies suggest it may regulate innate immune signaling by targeting viral proteins or host factors for degradation. In cancer, aberrant HERC4 expression has been associated with tumor suppression or oncogenic roles depending on context. The HERC4 antibody enables detection and functional analysis of HERC4 in techniques like Western blotting, immunofluorescence, or immunoprecipitation, aiding research into its molecular mechanisms. Commercial antibodies are typically developed in rabbits or mice, targeting specific epitopes within the HERC4 protein. Validation data (e.g., knockout controls) are critical to confirm specificity, as cross-reactivity with other HERC proteins is a potential concern. Research using HERC4 antibodies contributes to understanding its physiological and pathological roles, particularly in reproduction, immunity, and cancer biology.