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Mouse Monoclonal HERC4 Antibody

  • 中文名: HERC4抗体
  • 别    名: nan
货号: IPDX15761
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Rat
ImmunogenPurified recombinant fragment of human HERC4
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是3篇与HERC4抗体相关的研究文献概览:

1. **"HERC4 interacts with Claspin and regulates DNA replication progression"**

*Authors: Liu et al. (2018)*

**摘要**:研究利用HERC4特异性抗体进行免疫共沉淀实验,发现HERC4与DNA复制调控蛋白Claspin相互作用,通过调控ATR-Chk1信号通路影响细胞周期进程。抗体验证了HERC4在S期细胞核内的定位。

2. **"The HERC ubiquitin ligases in cancer: a focus on HERC4"**

*Authors: García-Cano et al. (2020)*

**摘要**:综述HERC家族泛素连接酶在肿瘤中的作用,其中通过HERC4抗体的Western blot分析显示,HERC4在乳腺癌中表达下调,可能通过泛素化降解促癌蛋白发挥抑癌功能。

3. **"Development of a monoclonal antibody targeting HERC4 for functional studies in Drosophila models"**

*Authors: Smith et al. (2019)*

**摘要**:报道了一种新型HERC4单克隆抗体的开发,验证了其在果蝇和人细胞中的特异性,并用于揭示HERC4在神经发育中通过调节突触蛋白稳定性影响认知功能的作用。

(注:以上文献信息为模拟示例,实际引用需核对真实数据库。)

背景信息

The HERC4 antibody is a tool used to study the HERC4 protein, a member of the HERC (HECT and RCC1-like domain-containing) family of ubiquitin ligases. HERC4. encoded by the *HERC4* gene in humans, plays roles in ubiquitination, a post-translational modification critical for protein degradation, trafficking, and signaling. It contains a HECT domain (responsible for ubiquitin ligase activity) and RCC1-like repeats (implicated in guanine nucleotide exchange). While less characterized than other HERC proteins (e.g., HERC1 or HERC2), HERC4 has been linked to cellular processes such as spermatogenesis, antiviral responses, and cancer progression. Studies suggest it may regulate innate immune signaling by targeting viral proteins or host factors for degradation. In cancer, aberrant HERC4 expression has been associated with tumor suppression or oncogenic roles depending on context. The HERC4 antibody enables detection and functional analysis of HERC4 in techniques like Western blotting, immunofluorescence, or immunoprecipitation, aiding research into its molecular mechanisms. Commercial antibodies are typically developed in rabbits or mice, targeting specific epitopes within the HERC4 protein. Validation data (e.g., knockout controls) are critical to confirm specificity, as cross-reactivity with other HERC proteins is a potential concern. Research using HERC4 antibodies contributes to understanding its physiological and pathological roles, particularly in reproduction, immunity, and cancer biology.

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