| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Purified recombinant fragment of human AREL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于AREL1抗体的虚构参考文献示例(注：AREL1并非广泛研究的蛋白，以下内容为模拟创作，仅供参考)：
1. **文献名称**：*AREL1 Antibody Characterization and Its Role in Unfolded Protein Response*
**作者**：Smith J, et al.
**摘要**：本研究开发并验证了一种特异性识别AREL1蛋白的单克隆抗体，证实其在Western blot和免疫荧光中的应用。研究发现AREL1与内质网应激反应中的未折叠蛋白通路(UPR)相关，可能通过调控ATF6信号通路影响细胞存活。
2. **文献名称**：*AREL1 Expression in Neurodegenerative Disorders: Insights from Immunohistochemical Analysis*
**作者**：Chen L, et al.
**摘要**：利用AREL1多克隆抗体对阿尔茨海默病模型小鼠脑组织进行分析，发现AREL1在神经元中的表达显著上调，提示其可能参与tau蛋白异常聚集的病理过程。
3. **文献名称**：*AREL1 Antibody Reveals Oncogenic Potential in Colorectal Cancer*
**作者**：Wang Y, et al.
**摘要**：通过AREL1抗体检测结直肠癌组织样本，发现AREL1高表达与患者预后不良相关。体外实验表明，抑制AREL1可降低癌细胞增殖和迁移能力。
4. **文献名称**：*Development of a High-Affinity AREL1 Antibody for Functional Proteomics Studies*
**作者**：Kumar R, et al.
**摘要**：报道了一种新型兔源多克隆抗体的开发，该抗体通过表位映射验证了特异性。研究利用该抗体进行质谱分析，揭示了AREL1与多个DNA损伤修复蛋白的相互作用。
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**注意**：以上文献为示例性质，实际研究中请通过学术数据库(如PubMed、Google Scholar)检索真实文献，并核实“AREL1”名称准确性(可能存在拼写或命名差异)。
The AREL1 (Apoptosis-Resistant E3 Ubiquitin-Protein Ligase 1) antibody is a research tool designed to detect AREL1. a protein implicated in cellular stress responses and apoptosis regulation. AREL1. also known as RNF216L, belongs to the RBR (RING-between-RING) family of E3 ubiquitin ligases, characterized by their role in ubiquitination—a post-translational modification critical for protein degradation, signaling, and homeostasis. Structurally, AREL1 contains a conserved RING domain essential for its enzymatic activity, enabling substrate recognition and ubiquitin transfer.
Biologically, AREL1 is linked to endoplasmic reticulum (ER)-associated degradation (ERAD) and the unfolded protein response (UPR), processes that mitigate ER stress by tagging misfolded proteins for proteasomal clearance. Dysregulation of AREL1 has been associated with neurodegenerative diseases, cancer, and immune disorders, where impaired protein homeostasis contributes to pathogenesis. For instance, AREL1 overexpression in certain cancers may promote cell survival by suppressing pro-apoptotic signals, highlighting its therapeutic relevance.
The AREL1 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study protein expression, localization, and interactions. It aids in exploring AREL1's role in disease mechanisms, drug response, and as a potential biomarker. Researchers prioritize validating antibody specificity using knockout controls to ensure accurate detection. Overall, AREL1 antibodies are pivotal in unraveling the protein's functional dynamics and its implications in health and disease.
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